{"id":"W2803969691","doi":"10.1021/acsinfecdis.8b00094","title":"Characterization of the Binding Sites for Bacterial Acyl Homoserine Lactones (AHLs) on Human Bitter Taste Receptors (T2Rs)","year":2018,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; University of Manitoba","keywords":"Quorum sensing; Biology; Innate immune system; Extracellular; Bacteria; Homoserine; Biochemistry; Receptor; Microbiology; Cell biology; Computational biology; Virulence; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001989383,0.0002959351,0.0002581363,0.0001287374,0.00009950688,0.0001404426,0.0001888547,0.0003240232,0.002050117],"category_scores_gemma":[0.0002638567,0.0001140413,0.0005072102,0.0001142269,0.0001165512,0.0001317687,0.0001372362,0.000234424,0.0006260897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883629,"about_ca_system_score_gemma":0.0001180587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094608,"about_ca_topic_score_gemma":0.0008612949,"domain_scores_codex":[0.9998447,0.00003868591,0.000008486989,0.00002798543,0.00003830415,0.00004191082],"domain_scores_gemma":[0.9998976,0.00003644873,0.0000177224,0.000008113211,0.00001815168,0.00002198786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004740332,0.00002544997,0.001499801,0.00004643457,0.00001850732,0.000101668,0.00002140255,0.0002352493,0.9953725,0.0000397362,0.00004627366,0.00211894],"study_design_scores_gemma":[0.000142977,0.001891457,0.06444719,0.00002496081,0.0001212333,0.001420625,0.000179373,0.01025002,0.9151889,0.0001263653,0.00617488,0.00003191556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942412,0.002301419,0.002256106,0.00007500725,0.00001199199,0.000026633,0.0004484749,0.00001645734,0.0006226675],"genre_scores_gemma":[0.9949752,0.0006418606,0.002281348,0.0000961992,0.0000082427,0.00001895183,0.0009458385,0.000007644282,0.001024824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002050117,"threshold_uncertainty_score":0.006858349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020012537474432,"score_gpt":0.286142606921269,"score_spread":0.2659424815465247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}