{"id":"W2803969691","doi":"10.1021/acsinfecdis.8b00094","title":"Characterization of the Binding Sites for Bacterial Acyl Homoserine Lactones (AHLs) on Human Bitter Taste Receptors (T2Rs)","year":2018,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; University of Manitoba","keywords":"Quorum sensing; Biology; Innate immune system; Extracellular; Bacteria; Homoserine; Biochemistry; Receptor; Microbiology; Cell biology; Computational biology; Virulence; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007201638,0.0001689993,0.0002302337,0.0001026484,0.0003320664,0.00006997277,0.0001449515,0.00009392967,0.0001032457],"category_scores_gemma":[0.000168606,0.0001202516,0.0001807705,0.0002532974,0.0001876618,0.0001085672,0.00006261043,0.00007092129,0.000008521853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004845629,"about_ca_system_score_gemma":0.000007660032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002662469,"about_ca_topic_score_gemma":0.0000236937,"domain_scores_codex":[0.9990792,0.00006813414,0.0002633136,0.0002499841,0.0001470139,0.0001923426],"domain_scores_gemma":[0.999172,0.00007848939,0.0002288769,0.0003145071,0.0001572161,0.00004885764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000128942,0.0001787092,0.03239403,0.00003894505,0.0000414837,1.017343e-7,0.00007394903,1.3041e-7,0.9643833,0.0001226522,0.00128031,0.001357417],"study_design_scores_gemma":[0.0003114655,0.000396888,0.02859412,0.0001067393,0.0001545728,0.000001097045,0.000007603382,0.00002117562,0.966607,0.0004726748,0.003154954,0.0001717341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982777,0.000004463923,0.00003746642,0.0003679736,0.0006505352,0.0002261404,0.0001108169,0.0001770019,0.0001478851],"genre_scores_gemma":[0.9983453,0.000004558635,0.00003003756,0.0003461121,0.000855097,0.00001907113,0.0002674691,0.00003091352,0.0001014896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003799913,"threshold_uncertainty_score":0.4903718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020012537474432,"score_gpt":0.286142606921269,"score_spread":0.2659424815465247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}