{"id":"W2803982612","doi":"10.1128/mbio.00819-18","title":"SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Doris Duke Charitable Foundation","keywords":"SAMHD1; Cyclin-dependent kinase 1; Small interfering RNA; Kinase; Dephosphorylation; Phosphorylation; Tyrosine kinase; Biology; Kinome; Cell biology; Signal transduction; Biochemistry; Reverse transcriptase; Cell culture; Transfection; Cell cycle; RNA; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009104169,0.0001782035,0.0001368816,0.0001052151,0.0001225349,0.0001732913,0.0001078792,0.0001207719,0.001539907],"category_scores_gemma":[0.00005506459,0.00007521427,0.0001314926,0.00008576577,0.000129137,0.00008562154,0.000108611,0.0002618646,0.0002382605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424209,"about_ca_system_score_gemma":0.0001172961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002145244,"about_ca_topic_score_gemma":0.0004708726,"domain_scores_codex":[0.9999267,0.00001315574,0.000005880549,0.00001407931,0.00001457964,0.00002565723],"domain_scores_gemma":[0.9999708,0.000004989821,0.000009331809,0.000003036181,0.000003232941,0.000008655464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977491,0.00002044617,0.0001678865,0.00002483315,0.000002838758,0.00001874038,0.000004668886,0.0000444668,0.9986138,0.00005142908,0.00003396857,0.0008191193],"study_design_scores_gemma":[0.00001704502,0.0001936857,0.004165789,0.000002978273,0.000005870025,0.00009180269,0.00001320854,0.0005456239,0.9934393,0.00002168589,0.0015013,0.000001709296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963857,0.001625367,0.0005693972,0.0000553793,0.00002648577,0.00001589236,0.0002175737,0.00002483958,0.001079285],"genre_scores_gemma":[0.9975058,0.0004627887,0.0005550872,0.00002379355,0.00000812336,0.00001678683,0.0001781439,0.000003657367,0.001245825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539907,"threshold_uncertainty_score":0.00515151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191158462686641,"score_gpt":0.2494417834891418,"score_spread":0.2375301988622754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}