{"id":"W2803982612","doi":"10.1128/mbio.00819-18","title":"SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Doris Duke Charitable Foundation","keywords":"SAMHD1; Cyclin-dependent kinase 1; Small interfering RNA; Kinase; Dephosphorylation; Phosphorylation; Tyrosine kinase; Biology; Kinome; Cell biology; Signal transduction; Biochemistry; Reverse transcriptase; Cell culture; Transfection; Cell cycle; RNA; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000225415,0.00009150384,0.00008967343,0.00004136728,0.000349697,0.00002472247,0.00005767741,0.00008045637,0.000578261],"category_scores_gemma":[0.00007964148,0.00006064447,0.00002389111,0.00007739604,0.0004978837,0.0000639297,0.00008231134,0.0001104335,0.001943528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003307671,"about_ca_system_score_gemma":0.00001871671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001292068,"about_ca_topic_score_gemma":0.0000348752,"domain_scores_codex":[0.9993036,0.0002049187,0.00009186323,0.0001698119,0.00002373661,0.0002060323],"domain_scores_gemma":[0.9996182,0.0001239278,0.00003109078,0.0001531711,0.00005086816,0.00002268038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00153633,0.0001500005,0.01044823,0.000003522291,0.00007896654,0.000009237452,0.0007270399,8.952168e-8,0.8289957,0.0001117855,0.1526239,0.005315171],"study_design_scores_gemma":[0.002093098,0.0009344701,0.06300018,0.00002859297,0.00002986212,0.00002983205,0.0004401148,0.000003751885,0.7979106,0.00007282879,0.1353373,0.0001193817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948717,0.001577903,0.00006847861,0.002611685,0.0001197471,0.0001852093,0.0002604142,0.00003259384,0.0002722309],"genre_scores_gemma":[0.9958609,0.00006713386,0.00001192837,0.0001297697,0.00001502117,0.00001526744,0.0003119305,0.00000644363,0.003581642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05255195,"threshold_uncertainty_score":0.9988336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191158462686641,"score_gpt":0.2494417834891418,"score_spread":0.2375301988622754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}