{"id":"W2804021114","doi":"10.1139/bcb-2017-0345","title":"Lentivirus-mediated down-regulation of CK2α inhibits proliferation and induces apoptosis of malignant lymphoma and leukemia cells","year":2018,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Department of Education, Heilongjiang Province","keywords":"Leukemia; Cell growth; Apoptosis; Cancer research; Molecular biology; Cell culture; Biology; Gene knockdown; Casein kinase 2; Cell cycle; Small hairpin RNA; Lymphoma; Proliferating cell nuclear antigen; Flow cytometry; Cyclin-dependent kinase 2; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212082,0.0003679507,0.000279929,0.0002837648,0.0001414911,0.0002591797,0.000234914,0.0002018321,0.0008300964],"category_scores_gemma":[0.0001012201,0.0001340088,0.0001942587,0.0002238091,0.0002114801,0.000212305,0.0001523824,0.0005501924,0.0002086011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003382036,"about_ca_system_score_gemma":0.0002640643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006644559,"about_ca_topic_score_gemma":0.0007367515,"domain_scores_codex":[0.9998216,0.00002630697,0.00002381561,0.00002991132,0.0000558914,0.00004247239],"domain_scores_gemma":[0.9999355,0.00001295863,0.00001905754,0.00001044979,0.000007819433,0.00001414918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007632308,0.00004741946,0.0001470609,0.00003831537,0.000006777645,0.00004031833,0.00001451518,0.0000766286,0.9976904,0.0002139848,0.00008607791,0.001562117],"study_design_scores_gemma":[0.00004993749,0.0002566937,0.00225002,0.000007375438,0.00002534839,0.0002199975,0.00001723034,0.002642021,0.9899429,0.00007265017,0.004511782,0.000004122492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838865,0.004718965,0.007761649,0.0001556026,0.0001005084,0.00008672256,0.0005754133,0.0002073005,0.002507278],"genre_scores_gemma":[0.9907655,0.001932194,0.003386291,0.00005990001,0.00001992517,0.0000723107,0.000927138,0.00002278201,0.002813952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008300964,"threshold_uncertainty_score":0.002776921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060776121778097,"score_gpt":0.2463892657134541,"score_spread":0.2357815044956731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}