{"id":"W2804057239","doi":"10.1002/hlca.201800066","title":"Fluorescent Nucleobase Analogues with Extended Pi Surfaces Stabilize <scp>DNA</scp> Duplexes Containing <i>O</i><sup>6</sup>‐Alkylguanine Adducts","year":2018,"lang":"en","type":"article","venue":"Helvetica Chimica Acta","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"European Research Council; Natural Sciences and Engineering Research Council of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Chemistry; Nucleobase; DNA; Nucleoside; Base pair; Adduct; AP site; Stereochemistry; Alkylation; Biochemistry; DNA damage; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002611931,0.0005951277,0.0005014272,0.0000671039,0.0003116739,0.0001280634,0.0006532808,0.0003520129,0.0002119885],"category_scores_gemma":[0.0004503805,0.0005071178,0.0001692707,0.0002171345,0.0009283119,0.00002346686,0.0003519705,0.0002968675,0.00006851839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004184796,"about_ca_system_score_gemma":0.0002113674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001583641,"about_ca_topic_score_gemma":0.00003645653,"domain_scores_codex":[0.9969234,0.0001071058,0.0004858425,0.00109164,0.0004390422,0.0009529766],"domain_scores_gemma":[0.9977968,0.00009813412,0.000220999,0.001107126,0.000333966,0.0004429148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003196658,0.0003036737,0.001550481,0.00007237527,0.0002035303,0.00002081373,0.0004765019,0.000005226468,0.9825917,0.00005540331,0.01422968,0.0001708904],"study_design_scores_gemma":[0.001624675,0.001517268,0.001795798,0.000105232,0.0001261667,0.0001030623,0.001448712,0.0004357016,0.9258156,0.00004554473,0.06660207,0.0003802219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938263,0.000303441,0.00003065163,0.0004055098,0.000127215,0.0003155824,0.0001450844,0.0001272288,0.004719023],"genre_scores_gemma":[0.9943573,0.000298189,0.002444626,0.0007451512,0.0007121005,0.00002925579,0.0004543231,0.0001226983,0.0008363689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0567762,"threshold_uncertainty_score":0.999738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0087786623961315,"score_gpt":0.2249235249243035,"score_spread":0.216144862528172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}