{"id":"W2804057239","doi":"10.1002/hlca.201800066","title":"Fluorescent Nucleobase Analogues with Extended Pi Surfaces Stabilize <scp>DNA</scp> Duplexes Containing <i>O</i><sup>6</sup>‐Alkylguanine Adducts","year":2018,"lang":"en","type":"article","venue":"Helvetica Chimica Acta","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"European Research Council; Natural Sciences and Engineering Research Council of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Chemistry; Nucleobase; DNA; Nucleoside; Base pair; Adduct; AP site; Stereochemistry; Alkylation; Biochemistry; DNA damage; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000090121,0.0002691631,0.0001641368,0.0000776579,0.00009721964,0.0001751945,0.0001815888,0.0002811087,0.001250382],"category_scores_gemma":[0.0003134595,0.0001273099,0.0001027758,0.00009730961,0.0002242632,0.0002506213,0.0001444604,0.0003250929,0.0003021063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608986,"about_ca_system_score_gemma":0.00007808764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002180811,"about_ca_topic_score_gemma":0.0002932559,"domain_scores_codex":[0.999931,0.00001252503,0.000002990043,0.00001972405,0.00001960407,0.00001420494],"domain_scores_gemma":[0.9998372,0.00005313681,0.00004313997,0.00001504336,0.00002155805,0.00002996609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003404802,0.000004116616,0.00005446731,0.0000125272,0.000002154246,0.00001312713,0.000008140273,0.00009580785,0.9989119,0.00004203147,0.000008600705,0.0008131413],"study_design_scores_gemma":[0.000003275242,0.0001649277,0.000776145,0.000001466848,0.000004739253,0.00004996637,0.000007845898,0.0003855241,0.9979758,0.00001367305,0.0006145313,0.000002072244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946703,0.0004789866,0.003524147,0.00002703019,0.000008256015,0.00001432928,0.00005645676,0.00005847593,0.001161898],"genre_scores_gemma":[0.9930576,0.0003983064,0.004990883,0.0000404958,0.000006203957,0.00002255148,0.000160709,0.00002291964,0.001300307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001250382,"threshold_uncertainty_score":0.004182935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0087786623961315,"score_gpt":0.2249235249243035,"score_spread":0.216144862528172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}