{"id":"W2804058066","doi":"10.1158/1078-0432.ccr-17-2745","title":"Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"National Cancer Institute","keywords":"Prostatectomy; Prostate cancer; Androgen deprivation therapy; Medicine; Oncology; Propensity score matching; Biochemical recurrence; Internal medicine; Metastasis; Proportional hazards model; Cancer; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003696305,0.0002886031,0.0006914488,0.0003618249,0.0003607588,0.00006557488,0.000201147,0.0003039193,0.0002209581],"category_scores_gemma":[0.0004207313,0.0002014689,0.0001845282,0.0006182124,0.001261988,0.0001544468,0.0002239354,0.0007609268,0.00003116889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001067203,"about_ca_system_score_gemma":0.004025847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004509205,"about_ca_topic_score_gemma":0.00009366137,"domain_scores_codex":[0.9954074,0.0007601172,0.0007397342,0.0008644502,0.00131194,0.0009163838],"domain_scores_gemma":[0.9973595,0.0007912388,0.0001483065,0.0004623366,0.0006007478,0.0006378363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07433496,0.001107908,0.7287999,0.0004292658,0.001439007,0.0003637243,0.008380097,0.000002247318,0.04083828,0.00002131973,0.001212797,0.1430705],"study_design_scores_gemma":[0.01960227,0.00825963,0.5855044,0.001330961,0.0002177806,0.00001092042,0.0004850247,0.00007122125,0.3309066,0.0001157976,0.05313395,0.0003614927],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879538,0.006246886,0.000003905365,0.002352127,0.0002888562,0.002807095,0.00007558266,0.00005610618,0.0002156775],"genre_scores_gemma":[0.9895328,0.00392954,0.0005865525,0.00007787009,0.0004499643,0.001183439,0.00004080485,0.00006232273,0.004136701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2900683,"threshold_uncertainty_score":0.8215661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1901585316872817,"score_gpt":0.4922202416215116,"score_spread":0.3020617099342299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}