{"id":"W2804079254","doi":"10.1016/j.stem.2018.04.020","title":"Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Biotechnology and Biological Sciences Research Council; University of East Anglia; National Institute for Health and Care Research; Medical Research Council Canada; Cancer Research UK; Cancer Research UK Cambridge Institute, University of Cambridge; NIHR Cambridge Biomedical Research Centre; Norfolk and Norwich University Hospitals NHS Foundation Trust; Wellcome Trust","keywords":"Biology; Crypt; Stem cell; Somatic cell; Genetics; Somatic evolution in cancer; Germline mutation; Mutant; Allele; Germline; Fixation (population genetics); Cell biology; Mutation; Gene; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005686962,0.00006915748,0.0000859282,0.00003222279,0.00003803045,0.000009320607,0.00006281365,0.00006770174,0.00001413863],"category_scores_gemma":[0.000006806398,0.00007331763,0.00002271518,0.00004175145,0.00007021002,0.000001709596,0.00004274509,0.00002794424,0.00001055487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000115233,"about_ca_system_score_gemma":0.00003911431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008845305,"about_ca_topic_score_gemma":0.0004291929,"domain_scores_codex":[0.9995155,0.00001870755,0.0001688408,0.0001514029,0.00004163791,0.0001039319],"domain_scores_gemma":[0.9996375,0.00001912846,0.00008991455,0.0001585317,0.00006215778,0.00003273356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001519563,0.00008714167,0.006815805,0.00009941176,0.000004847815,8.818878e-7,0.000396592,0.00004376825,0.9915365,0.0001088153,0.0003768084,0.0005142628],"study_design_scores_gemma":[0.0007186869,0.0003812162,0.007840924,0.00001809541,0.00001671259,0.000001140005,0.0002097134,0.0002284968,0.9887853,0.0001716383,0.00151813,0.0001099473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944678,0.0004164182,0.0001508434,0.00002396242,0.00006903362,0.0001446511,0.00002032975,0.000002631939,0.004704361],"genre_scores_gemma":[0.9990255,0.0001575439,0.0001797158,0.00005483117,0.00007039207,0.00001089505,0.00004797391,0.00001025414,0.0004428523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004557773,"threshold_uncertainty_score":0.2989806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006786568604198995,"score_gpt":0.2286448229567094,"score_spread":0.2218582543525104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}