{"id":"W2804079254","doi":"10.1016/j.stem.2018.04.020","title":"Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Biotechnology and Biological Sciences Research Council; University of East Anglia; National Institute for Health and Care Research; Medical Research Council Canada; Cancer Research UK; Cancer Research UK Cambridge Institute, University of Cambridge; NIHR Cambridge Biomedical Research Centre; Norfolk and Norwich University Hospitals NHS Foundation Trust; Wellcome Trust","keywords":"Biology; Crypt; Stem cell; Somatic cell; Genetics; Somatic evolution in cancer; Germline mutation; Mutant; Allele; Germline; Fixation (population genetics); Cell biology; Mutation; Gene; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772048,0.0001230042,0.000135001,0.0002753098,0.0001241341,0.0001925171,0.0001589449,0.0002790925,0.0006166527],"category_scores_gemma":[0.0003240318,0.0001491446,0.0001673989,0.0001803765,0.0001749119,0.0001780999,0.0001955097,0.0002719222,0.0001393763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002657127,"about_ca_system_score_gemma":0.0001726122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001876051,"about_ca_topic_score_gemma":0.001724447,"domain_scores_codex":[0.9999167,0.00001181823,0.000004524286,0.00002493168,0.00002639054,0.00001572699],"domain_scores_gemma":[0.9998586,0.00005270441,0.00003676464,0.00001376123,0.00002100415,0.0000172441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001535479,0.00001437624,0.003854842,0.00003315221,0.000007712902,0.0001554973,0.00005963903,0.001534255,0.9886073,0.0004509029,0.00002191973,0.005106978],"study_design_scores_gemma":[0.0000325896,0.00094445,0.04975704,0.00001726607,0.00004410348,0.001225991,0.0002121496,0.02457589,0.9206924,0.0007045293,0.001768942,0.00002468692],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925435,0.0008400854,0.005972052,0.00002085323,0.000002732209,0.0000068319,0.00006731979,0.00002147168,0.0005251062],"genre_scores_gemma":[0.9953625,0.0003561685,0.003583846,0.000008926025,0.000001500736,0.00000680328,0.00006772592,0.000006573747,0.0006058339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876051,"threshold_uncertainty_score":0.003730297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006786568604198995,"score_gpt":0.2286448229567094,"score_spread":0.2218582543525104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}