{"id":"W2804085823","doi":"10.1016/s2213-2600(18)30201-7","title":"Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada); McGill University Health Centre; University of British Columbia","funders":"Medical Research Council; Odense Universitetshospital; University of Leicester; National Institute for Health and Care Research; NIHR Great Ormond Street Hospital Biomedical Research Centre; GlaxoSmithKline; Asthma and Lung UK; AstraZeneca","keywords":"Medicine; Placebo; Asthma; Mepolizumab; Monoclonal antibody; Eosinophilic; Double blind; Interleukin 5; Internal medicine; Eosinophilic esophagitis; Gastroenterology; Inflammation; Monoclonal; Interleukin; Immunology; Antibody; Pathology; Eosinophil; Cytokine; Disease; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001850517,0.002234078,0.004019066,0.0004356378,0.0005148277,0.001161091,0.001197473,0.002140364,0.005099828],"category_scores_gemma":[0.001532828,0.0007818529,0.002891276,0.0003366052,0.001361858,0.001202963,0.0004084786,0.003339417,0.00103553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006988535,"about_ca_system_score_gemma":0.000793484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211864,"about_ca_topic_score_gemma":0.002507146,"domain_scores_codex":[0.9994387,0.0002443442,0.00003912036,0.000122217,0.00004636045,0.0001092734],"domain_scores_gemma":[0.9992673,0.0002218693,0.0001514333,0.00005203089,0.00004717341,0.000260257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9866659,0.001793253,0.0002359548,0.0007920294,0.0007973376,0.00003618935,0.00003428981,0.0001565411,0.00269461,0.00004789234,0.0004280415,0.006317817],"study_design_scores_gemma":[0.9600521,0.03754238,0.00127347,0.00002722555,0.0004328604,0.00002776129,0.00001442418,0.0001498167,0.0001973142,0.0000432693,0.0002260629,0.00001339702],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856535,0.008503145,0.0004563434,0.0006875393,0.0008368849,0.001577206,0.0007861712,0.0001282067,0.001371153],"genre_scores_gemma":[0.9869366,0.004257753,0.0009591957,0.0009930748,0.0005843706,0.001903806,0.0009045766,0.00002775061,0.003432837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005099828,"threshold_uncertainty_score":0.01706064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03919430931402542,"score_gpt":0.3744604178185523,"score_spread":0.3352661085045269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}