{"id":"W2804143759","doi":"10.1128/aac.01224-17","title":"New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis","year":2017,"lang":"en","type":"letter","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Aztreonam; Sulbactam; Avibactam; Clavulanic acid; Beta-Lactamase Inhibitors; Cephalosporin; Antibiotics; Lactam; Chemistry; Tazobactam; Microbiology; Hydrolysis; Medicine; Biochemistry; Amoxicillin; Stereochemistry; Biology; Klebsiella pneumoniae; Antibiotic resistance; Imipenem; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006754118,0.0006470023,0.0004624625,0.0002583431,0.0007232477,0.001503643,0.000806387,0.008743582,0.003774777],"category_scores_gemma":[0.005301553,0.0003023732,0.0005251172,0.0002894315,0.001550613,0.001046281,0.0007498526,0.005722881,0.007723937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002058497,"about_ca_system_score_gemma":0.0006262793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008883495,"about_ca_topic_score_gemma":0.0008337537,"domain_scores_codex":[0.9991311,0.0002863971,0.00007857271,0.0001100067,0.0002098684,0.0001839784],"domain_scores_gemma":[0.9987282,0.0006788903,0.0001977295,0.0001116272,0.0001429199,0.0001406647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000631219,0.0001919407,0.006290148,0.0005138508,0.00007960035,0.1321664,0.000567672,0.0008136905,0.02027391,0.03595787,0.7322395,0.07027424],"study_design_scores_gemma":[0.0003944986,0.000233529,0.001597275,0.0002050705,0.00004666814,0.0658351,0.0005322949,0.001744855,0.01863996,0.03194715,0.8787593,0.00006428998],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02753729,0.02079914,0.00307467,0.877821,0.01914947,0.0001123454,0.0002168438,0.0003292112,0.05095993],"genre_scores_gemma":[0.480991,0.04784937,0.003585628,0.3557078,0.04507351,0.0002879011,0.0003601213,0.0001084484,0.06603622],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008743582,"threshold_uncertainty_score":0.01493549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009280865093270871,"score_gpt":0.2414623306491975,"score_spread":0.2321814655559266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}