{"id":"W2804145461","doi":"10.1016/j.neulet.2018.05.019","title":"Lipid roles in hERG function and interactions with drugs","year":2018,"lang":"en","type":"review","venue":"Neuroscience Letters","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"hERG; Potassium channel; Phospholipidosis; Long QT syndrome; Ion channel; Pharmacology; Chemistry; Potassium channel blocker; Neuroscience; Biology; Biochemistry; QT interval; Medicine; Biophysics; Membrane; Internal medicine; Phospholipid; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000269719,0.0006881138,0.000895407,0.001275464,0.0001605896,0.0009095676,0.0003808326,0.0008564713,0.002916643],"category_scores_gemma":[0.0005624134,0.0001722945,0.000244319,0.001039977,0.0004470205,0.001084266,0.0008122401,0.001110235,0.001109257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003600324,"about_ca_system_score_gemma":0.0005986152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004341489,"about_ca_topic_score_gemma":0.000874649,"domain_scores_codex":[0.9999065,0.00001750321,0.00002003602,0.00001455607,0.00002907474,0.00001233086],"domain_scores_gemma":[0.999836,0.00008048538,0.00003467071,0.000005871168,0.00002823115,0.00001468428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001771887,0.00006316484,0.0002831138,0.01015265,0.0001050041,0.0006313731,0.00006537831,0.0003585118,0.003102703,0.003999584,0.0220186,0.9590427],"study_design_scores_gemma":[0.00003314809,0.0001071575,0.0007999614,0.00253501,0.0001580378,0.001977222,0.00007766187,0.0001275071,0.001163058,0.002786288,0.9902159,0.00001912429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000274043,0.9974515,0.0001558681,0.0005031259,0.0002426137,0.000002932436,0.00001845078,0.000005933385,0.00134551],"genre_scores_gemma":[0.001939698,0.9960455,0.0001752429,0.000276929,0.0004477951,0.00000521666,0.00002717811,0.000001522565,0.001080886],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002916643,"threshold_uncertainty_score":0.009757102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868223960795412,"score_gpt":0.2937486780903116,"score_spread":0.2750664384823575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}