{"id":"W2804151471","doi":"10.1186/s12974-018-1128-2","title":"Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury","year":2018,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Children's Hospital Research Institute of Manitoba; Rick Hansen Institute; Research Manitoba; Natural Sciences and Engineering Research Council of Canada; Craig H. Neilsen Foundation","keywords":"Receptor; Spinal cord injury; Inflammation; Chondroitin sulfate; Spinal cord; Neuroscience; Proteoglycan; Medicine; Neurology; Inflammatory response; Signal transduction; Cell biology; Chemistry; Immunology; Biology; Internal medicine; Anatomy; Glycosaminoglycan; Cartilage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964539,0.0004377751,0.0004007193,0.0002975661,0.0002198253,0.000284867,0.0002058572,0.0003210185,0.001393413],"category_scores_gemma":[0.0001183127,0.0001249847,0.0004036143,0.0001712501,0.0004225119,0.0002872044,0.0002014574,0.000820333,0.0003633726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003688392,"about_ca_system_score_gemma":0.0005122708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000613877,"about_ca_topic_score_gemma":0.001159035,"domain_scores_codex":[0.9997932,0.0000188022,0.00001975664,0.00003500057,0.00004864324,0.00008456745],"domain_scores_gemma":[0.9998863,0.00001046898,0.00003775627,0.000008202886,0.00001704363,0.00004021059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001131934,0.00003527475,0.0001210128,0.00004096788,0.000003341952,0.00002566795,0.000008432645,0.00002812378,0.9990259,0.00002979576,0.00001361991,0.0005547137],"study_design_scores_gemma":[0.00002318324,0.001059459,0.005904773,0.0000107536,0.00003149846,0.0001642304,0.00005159167,0.0004039558,0.9918311,0.00002919804,0.0004856798,0.000004603251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944741,0.001322478,0.002758828,0.0001358955,0.00002866358,0.00004848861,0.000207648,0.00006796147,0.0009558587],"genre_scores_gemma":[0.9933873,0.001875439,0.002524353,0.0001047505,0.00002704727,0.0001065302,0.0003330241,0.00001004181,0.001631485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393413,"threshold_uncertainty_score":0.004661441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03301388784475235,"score_gpt":0.3039495349262336,"score_spread":0.2709356470814813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}