{"id":"W2804158481","doi":"10.1093/ibd/izy007","title":"Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study","year":2018,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; Fonds de recherche du Québec; Swim Across America","keywords":"Inflammatory bowel disease; Sphingolipid; Medicine; Sphingosine kinase; S1PR1; Ulcerative colitis; Sphingosine; Sphingosine-1-phosphate receptor; Internal medicine; Ceramide; Population; Immunology; Gastroenterology; Sphingosine-1-phosphate; Disease; Biology; Receptor; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005233036,0.0004943878,0.000576844,0.0006656465,0.000605759,0.0003630531,0.0003096646,0.000424636,0.002267579],"category_scores_gemma":[0.001031262,0.0002587819,0.0003785186,0.0006415234,0.0004125428,0.0002913201,0.0003307901,0.000286043,0.0002901182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003458736,"about_ca_system_score_gemma":0.0003352862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313334,"about_ca_topic_score_gemma":0.001125129,"domain_scores_codex":[0.9994711,0.0001225321,0.00003987217,0.0002243953,0.00008040568,0.00006166923],"domain_scores_gemma":[0.9994987,0.0001149135,0.0001671304,0.00006897042,0.00007070911,0.00007959946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002428389,0.0005903238,0.982716,0.00009202927,0.0001224402,0.002094996,0.000265668,0.00007896825,0.005742888,0.00009874694,0.0001767369,0.005592776],"study_design_scores_gemma":[0.0001884874,0.004030818,0.9861837,0.00001513752,0.0001724292,0.006433779,0.0004498045,0.0003015575,0.00105186,0.00006125222,0.001102854,0.000008385917],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989661,0.000190629,0.0003936306,0.000009718365,0.000004063661,0.00007883885,0.0001584715,0.000004866642,0.000193754],"genre_scores_gemma":[0.99844,0.0001562355,0.0006789643,0.00002121516,0.00001576832,0.0001191139,0.0003923393,0.000004622783,0.000171875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002267579,"threshold_uncertainty_score":0.007585764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007592702405238239,"score_gpt":0.2305920195695095,"score_spread":0.2229993171642712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}