{"id":"W2804159523","doi":"10.1111/tpj.13975","title":"Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy","year":2018,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Opium Poppy; Papaver; Thebaine; Biology; Biochemistry; Saccharomyces cerevisiae; Poppy; Stereochemistry; Yeast; Codeine; Chemistry; Morphine; Pharmacology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000106919,0.0003132086,0.0002523847,0.0003700359,0.0001701606,0.0003306586,0.0001629159,0.0001968559,0.0005262854],"category_scores_gemma":[0.0001753654,0.0001688655,0.000316634,0.0003393738,0.0001912788,0.0001470845,0.0002894389,0.0004420181,0.0002803737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003516149,"about_ca_system_score_gemma":0.0001746446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00175027,"about_ca_topic_score_gemma":0.00175564,"domain_scores_codex":[0.9998621,0.00001102729,0.00001179899,0.00004020191,0.00004475874,0.00003006823],"domain_scores_gemma":[0.9998411,0.00002274774,0.00004570909,0.00001992366,0.00002732959,0.00004332179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003397689,0.000003428453,0.0001437385,0.000007519631,0.000002221805,0.0000217234,0.00001037956,0.00001073376,0.9993796,0.00001590222,0.000006596678,0.0003641043],"study_design_scores_gemma":[0.00001140477,0.00008791337,0.03143523,0.000004741347,0.00004031767,0.000613976,0.0000574757,0.0006763221,0.9641503,0.00005099957,0.002856947,0.00001438361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958177,0.0006576424,0.002026954,0.00005595457,0.00001097745,0.00001860814,0.0007439951,0.00006989214,0.0005983204],"genre_scores_gemma":[0.9899767,0.0005136388,0.002460248,0.00005686692,0.000006084147,0.00002942125,0.002399652,0.00007406934,0.004483267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00175027,"threshold_uncertainty_score":0.003480196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03330150584043341,"score_gpt":0.2840021629852543,"score_spread":0.2507006571448209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}