{"id":"W2804171243","doi":"10.1002/pep2.24078","title":"Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor","year":2018,"lang":"en","type":"article","venue":"Peptide Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Enantiomer; Chemistry; Stereochemistry; Agonist; Affinities; Receptor; Peptide; Opioid receptor; Cyclic peptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215161,0.0003158549,0.0002566037,0.0002039156,0.0001034495,0.0002293114,0.0002371925,0.0002632436,0.001339059],"category_scores_gemma":[0.0003365783,0.0001754012,0.0001791501,0.000130153,0.0001752675,0.0001808696,0.0001513168,0.000354546,0.0002594119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299496,"about_ca_system_score_gemma":0.0002265015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002634553,"about_ca_topic_score_gemma":0.0003806547,"domain_scores_codex":[0.999728,0.00007414978,0.00002647707,0.00003923984,0.00006736827,0.00006476043],"domain_scores_gemma":[0.9997975,0.00004103387,0.00005448457,0.00002673687,0.0000271087,0.00005316587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000574288,0.00006454996,0.0002305136,0.00004759494,0.00001360147,0.0000828808,0.00001434931,0.0002384775,0.995681,0.0002408736,0.00007444827,0.002737402],"study_design_scores_gemma":[0.0001130515,0.002661628,0.002075549,0.000007359108,0.00002777203,0.0003953019,0.00002217027,0.0008677373,0.9915848,0.00007563113,0.002154152,0.00001483794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953396,0.0007643488,0.001253492,0.00003781184,0.00003594246,0.00005168463,0.0003403033,0.00002035936,0.00215639],"genre_scores_gemma":[0.9950333,0.0004040149,0.002809288,0.00009480792,0.00001603048,0.00005972405,0.0003864872,0.00001128396,0.001185059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339059,"threshold_uncertainty_score":0.004479587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163647031589453,"score_gpt":0.260609446199653,"score_spread":0.2489729758837585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}