{"id":"W2804175295","doi":"10.7759/cureus.2652","title":"A Review of the Mechanism of Antagonism of N-methyl-D-aspartate Receptor by Ketamine in Treatment-resistant Depression","year":2018,"lang":"en","type":"review","venue":"Cureus","topic":"Treatment of Major Depression","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"NMDA receptor; Synaptogenesis; Ketamine; Long-term potentiation; Glutamate receptor; Neurotrophic factors; Neuroscience; Antidepressant; Depression (economics); Norepinephrine; Brain-derived neurotrophic factor; Mechanism (biology); Treatment-resistant depression; Dopamine; Psychology; Pharmacology; Hippocampus; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004408837,0.0005799346,0.003621667,0.0001401984,0.00002966595,0.000002724168,0.0004165628,0.000382428,0.0002253465],"category_scores_gemma":[0.0003367302,0.0002984044,0.0009211862,0.0004606182,0.0001701652,0.00004897262,0.0001662102,0.0002135127,0.00001331835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002891834,"about_ca_system_score_gemma":0.000357803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001986896,"about_ca_topic_score_gemma":0.00001853195,"domain_scores_codex":[0.9965236,0.0004768548,0.001651791,0.0005391397,0.0005236838,0.000284972],"domain_scores_gemma":[0.9960368,0.0002458957,0.001944541,0.001495609,0.0001680934,0.0001090178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002721793,0.003059421,0.0001217513,0.3608258,0.001339085,0.00002193607,0.0001576756,2.590976e-8,0.01836549,0.00008871494,0.01415433,0.6015936],"study_design_scores_gemma":[0.00143101,0.0008510065,0.00001905972,0.362454,0.003292918,0.00001712177,0.000007612232,5.08773e-7,0.03065703,0.00002288768,0.601064,0.0001828041],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003561685,0.9953061,0.000003411455,0.0000542995,0.0003339135,0.002821391,0.0005973201,0.00001826511,0.0005091436],"genre_scores_gemma":[0.0001959756,0.9977634,0.0004018688,0.00002958876,0.00006178929,0.0001868282,0.0003742513,0.00007740876,0.0009089147],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6014107,"threshold_uncertainty_score":0.9999468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04241140764655349,"score_gpt":0.3507100512077321,"score_spread":0.3082986435611786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}