{"id":"W2804175295","doi":"10.7759/cureus.2652","title":"A Review of the Mechanism of Antagonism of N-methyl-D-aspartate Receptor by Ketamine in Treatment-resistant Depression","year":2018,"lang":"en","type":"review","venue":"Cureus","topic":"Treatment of Major Depression","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"NMDA receptor; Synaptogenesis; Ketamine; Long-term potentiation; Glutamate receptor; Neurotrophic factors; Neuroscience; Antidepressant; Depression (economics); Norepinephrine; Brain-derived neurotrophic factor; Mechanism (biology); Treatment-resistant depression; Dopamine; Psychology; Pharmacology; Hippocampus; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003820352,0.0007342495,0.001122665,0.002097283,0.0002322542,0.0006241472,0.0008079719,0.0007441049,0.003958474],"category_scores_gemma":[0.0007024552,0.000247998,0.0006696721,0.001972338,0.0002448514,0.0008968009,0.0004358717,0.001166745,0.00138727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003991516,"about_ca_system_score_gemma":0.0007483656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009217014,"about_ca_topic_score_gemma":0.001836946,"domain_scores_codex":[0.9998652,0.00002365983,0.00003826539,0.00002443535,0.00003775962,0.00001065431],"domain_scores_gemma":[0.9997708,0.0001129206,0.00004362525,0.00000602066,0.00004813734,0.00001850844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009430548,0.0000903423,0.0001429426,0.04760275,0.0001693944,0.0002410148,0.00008119312,0.0002550338,0.001433699,0.002420921,0.0372773,0.9101911],"study_design_scores_gemma":[0.00003581838,0.0001799218,0.00110796,0.01081067,0.0003346939,0.001871205,0.00005990538,0.00008943608,0.0003533331,0.001303125,0.9838318,0.00002207681],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008592109,0.9990357,0.00005919614,0.0001601558,0.0001355017,0.0000049154,0.00001927215,0.000004212435,0.0004951907],"genre_scores_gemma":[0.0004601099,0.9989398,0.0001246195,0.0001120744,0.00009234453,0.000005455021,0.00002372436,8.226563e-7,0.0002410039],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003958474,"threshold_uncertainty_score":0.01324236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04241140764655349,"score_gpt":0.3507100512077321,"score_spread":0.3082986435611786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}