{"id":"W2804182232","doi":"10.1038/s41589-018-0059-7","title":"A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis","year":2018,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Research Council Canada; McGill University","keywords":"Thebaine; Opium Poppy; Chemistry; Biosynthesis; Biochemistry; Poppy; Enzyme; Codeine; Alkaloid; Morphine; Stereochemistry; Papaver; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005660221,0.001069305,0.0005274586,0.0003359015,0.0007692647,0.0007395406,0.0004697315,0.001323526,0.002655271],"category_scores_gemma":[0.0003663787,0.0004260376,0.000708941,0.000243431,0.000521428,0.0007348022,0.0005955782,0.001473318,0.00264962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001219151,"about_ca_system_score_gemma":0.0009743403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001556548,"about_ca_topic_score_gemma":0.002035806,"domain_scores_codex":[0.999626,0.00006088642,0.00001906693,0.0001125263,0.00008873331,0.00009272921],"domain_scores_gemma":[0.9996359,0.00005916775,0.000062662,0.00003831449,0.00006956342,0.0001342389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002245679,0.00007925963,0.0009269332,0.0001249961,0.00001284761,0.0003251724,0.00006632622,0.0001031689,0.9936087,0.0008748351,0.0004853412,0.003167972],"study_design_scores_gemma":[0.00003087889,0.0002833438,0.00983154,0.00002466439,0.00002319943,0.001228738,0.000127592,0.001518136,0.9681628,0.0009042976,0.01784188,0.00002281283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9388469,0.008652319,0.03569772,0.001703762,0.0007157414,0.0002902096,0.001647966,0.002173622,0.01027188],"genre_scores_gemma":[0.9192066,0.00266178,0.04535743,0.000400541,0.00008678901,0.00009079093,0.004392142,0.0002335192,0.02757033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002655271,"threshold_uncertainty_score":0.008882761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719679710635464,"score_gpt":0.3115747969708584,"score_spread":0.2943779998645038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}