{"id":"W2804202266","doi":"10.1038/s41379-018-0050-6","title":"Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas","year":2018,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale; Advanced Remanufacturing and Technology Centre; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Institute of Cancer Research; Institut National Du Cancer; Direction Générale de l’offre de Soins","keywords":"Pilocytic astrocytoma; Glioma; Fusion gene; Ganglioglioma; Oligodendroglioma; Pathology; Astrocytoma; Fusion transcript; Medicine; Cancer research; Biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217014,0.0002347701,0.0004540476,0.000194648,0.0001192938,0.00003464167,0.00009881024,0.0001632562,0.00002732725],"category_scores_gemma":[0.000080353,0.000212153,0.00008207178,0.0001402979,0.0001654866,0.0002863029,0.0000766343,0.0001150793,0.000009943565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007140837,"about_ca_system_score_gemma":0.00003330573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001856185,"about_ca_topic_score_gemma":0.0002973486,"domain_scores_codex":[0.9984721,0.00005327413,0.0004343759,0.0005545933,0.0001553296,0.0003303218],"domain_scores_gemma":[0.9989418,0.0001552572,0.000235009,0.0003685395,0.0001609621,0.0001384241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002507363,0.001956389,0.03383999,0.00006372746,0.0002621994,0.000141429,0.006791015,0.0001047619,0.7932625,0.0001892506,0.0001752474,0.1607061],"study_design_scores_gemma":[0.0122425,0.004866184,0.06350512,0.0001308156,0.0002694165,0.0001910032,0.0004014084,0.1740712,0.7400836,0.003656166,0.0002099309,0.0003726441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9040045,0.0001520007,0.09422448,0.0003650827,0.00007262493,0.0007267179,0.0003748535,0.00004151523,0.00003827223],"genre_scores_gemma":[0.9951038,0.00003347986,0.003847379,0.0002273218,0.00009472733,0.0002316054,0.0004022874,0.00003513298,0.00002421685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1739664,"threshold_uncertainty_score":0.8651348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081414495279137,"score_gpt":0.295972583620931,"score_spread":0.2651584386681397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}