{"id":"W2804223529","doi":"10.1186/s12885-020-07078-8","title":"DNA methylation signatures of Prostate Cancer in peripheral T-cells","year":2020,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University Health Centre; University of Calgary; McGill University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Prostate cancer; Methylation; Immune system; Cancer; Biology; Medicine; Cancer research; Oncology; Internal medicine; Immunology; DNA; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000732979,0.00008928086,0.00011417,0.00002077448,0.00001507062,0.00000825893,0.0000708701,0.00009265409,0.00008928058],"category_scores_gemma":[0.00002437946,0.00008601026,0.00004805638,0.0001115446,0.00002711027,0.000003396632,0.00003198504,0.00005734569,7.559002e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001794288,"about_ca_system_score_gemma":0.0001242126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002294544,"about_ca_topic_score_gemma":0.001004884,"domain_scores_codex":[0.9993437,0.00004463341,0.0001773986,0.000215566,0.00009764517,0.0001210438],"domain_scores_gemma":[0.999704,0.00000671596,0.00008687474,0.00009582538,0.0000612225,0.00004535718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001122811,0.00001281338,0.02496217,0.00004245974,0.00001141705,2.585148e-7,0.000249608,0.02541788,0.9442936,0.00001219838,0.0001738742,0.004711438],"study_design_scores_gemma":[0.0004650695,0.00008901863,0.02012749,0.00001519474,0.000009118146,2.308002e-8,0.00003221536,0.001137229,0.9683971,0.0000436461,0.009569664,0.0001141766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834206,0.01498436,0.0006941346,0.0001934055,0.0001349181,0.0001913514,0.0000591543,0.000004705979,0.00031734],"genre_scores_gemma":[0.9970383,0.001857145,0.0004152921,0.0001586183,0.0002089672,0.00004686644,0.00002452667,0.00001522851,0.0002350575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02428065,"threshold_uncertainty_score":0.3507397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670412596763941,"score_gpt":0.2846254570367809,"score_spread":0.2679213310691415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}