{"id":"W2804226791","doi":"10.1016/j.mex.2018.05.004","title":"Tools and protocol for quantification of myosin phosphorylation with MRM-MS","year":2018,"lang":"en","type":"article","venue":"MethodsX","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Phosphorylation; Myosin; Chemistry; Mass spectrometry; Chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006255503,0.00007082647,0.0002159228,0.00003933247,0.0000637714,0.000008439711,0.00001885923,0.00003827534,0.000008630728],"category_scores_gemma":[0.0002368499,0.00005012376,0.00003520361,0.0001067829,0.00017603,0.00005207869,0.00001214365,0.00003112467,0.000001160032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001176106,"about_ca_system_score_gemma":0.0000278491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001404462,"about_ca_topic_score_gemma":0.000003540924,"domain_scores_codex":[0.9994663,0.00004686699,0.0001516606,0.0001528928,0.00009663828,0.00008562994],"domain_scores_gemma":[0.9993247,0.0001556264,0.00008722943,0.0001591826,0.0002459557,0.00002733006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007648785,0.0002231,0.0243109,0.001294963,0.0002545845,0.000002282847,0.004037675,0.00000242336,0.1901967,0.005324921,0.002437323,0.7642663],"study_design_scores_gemma":[0.004024452,0.002040056,0.1703957,0.0002654782,0.0002197951,0.00002658121,0.0003132496,0.0002450185,0.6411126,0.0007164882,0.1804894,0.0001511278],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.05322457,0.00009005582,0.785508,0.0005190774,0.0001076615,0.1553741,0.00002610669,0.00006454383,0.005085888],"genre_scores_gemma":[0.1413488,0.000006235563,0.6997895,0.0001348406,0.0003947505,0.1574296,0.00001495199,0.00002927859,0.0008520815],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.7641152,"threshold_uncertainty_score":0.2043988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1301371693275134,"score_gpt":0.4313514915773894,"score_spread":0.301214322249876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}