{"id":"W2804261193","doi":"10.1038/s41594-018-0065-1","title":"Dissection of DNA double-strand-break repair using novel single-molecule forceps","year":2018,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Synapsis; DNA; DNA ligase; DNA repair protein XRCC4; Cell biology; Ku70; Ku80; Biophysics; DNA repair; Biology; Sticky and blunt ends; Molecular biology; Chemistry; Genetics; DNA-binding protein; Recombination; Gene; DNA mismatch repair; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220386,0.0002991502,0.0001958847,0.000226872,0.0004310565,0.0003941957,0.0005808602,0.0007266949,0.001170149],"category_scores_gemma":[0.0002270241,0.0003067758,0.0002504908,0.00008680969,0.0003364128,0.0004632937,0.0003226102,0.0008695331,0.0003763934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006290243,"about_ca_system_score_gemma":0.0003727503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320685,"about_ca_topic_score_gemma":0.002730932,"domain_scores_codex":[0.9998977,0.000005916797,0.000006419132,0.00003136246,0.0000385489,0.00002002715],"domain_scores_gemma":[0.9998173,0.00005840186,0.00003977361,0.00002052017,0.00001974561,0.0000442116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001594116,0.00001140616,0.000074233,0.00001807269,0.000003259151,0.00004440901,0.00001258829,0.000187084,0.9983591,0.0002494621,0.00004924756,0.0009751553],"study_design_scores_gemma":[0.00001390688,0.00004177631,0.001365245,0.000004861359,0.000005082916,0.0002038645,0.00002590151,0.006112634,0.9894562,0.0002115105,0.002550815,0.000008216403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9462889,0.0009895811,0.04745602,0.0009029434,0.0001035231,0.0001397467,0.0004627577,0.0002913954,0.003365034],"genre_scores_gemma":[0.95315,0.001005852,0.04009843,0.0001975528,0.00002272642,0.0001063583,0.0003303612,0.00004836828,0.005040391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320685,"threshold_uncertainty_score":0.004563928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037070913528388,"score_gpt":0.3241761428805372,"score_spread":0.3138054337452533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}