{"id":"W2804288285","doi":"10.3389/fimmu.2018.01199","title":"Streptococcus suis Serotype 2 Infection Impairs Interleukin-12 Production and the MHC-II-Restricted Antigen Presentation Capacity of Dendritic Cells","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Zoetis","keywords":"Antigen presentation; CIITA; Streptococcus suis; Biology; Dendritic cell; Antigen; MHC class II; T cell; Antigen-presenting cell; Major histocompatibility complex; Immunology; Cell biology; Immune system; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001905764,0.0005557187,0.000347034,0.0001914191,0.00009254716,0.000339583,0.000119998,0.000287369,0.001149182],"category_scores_gemma":[0.0001410812,0.0001796324,0.0002332561,0.0001238462,0.0001762909,0.0001645133,0.000166925,0.0005656804,0.0003516358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186601,"about_ca_system_score_gemma":0.000272647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004466005,"about_ca_topic_score_gemma":0.0005732505,"domain_scores_codex":[0.999719,0.00006014486,0.00003607286,0.00003479938,0.0000521004,0.00009783743],"domain_scores_gemma":[0.9998618,0.00002439122,0.00003725251,0.00001683242,0.00001095547,0.00004868524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003830691,0.00009649768,0.0002087748,0.00003247912,0.00000267226,0.0000367362,0.00001631134,0.00002775904,0.998546,0.00001988022,0.00002796492,0.0006019616],"study_design_scores_gemma":[0.0000554533,0.002388497,0.01332715,0.00001715455,0.00002442235,0.0002863234,0.00009373424,0.001081125,0.9803874,0.0000515937,0.00227733,0.000009698487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981108,0.000724685,0.0003354154,0.00004794347,0.00002974698,0.00001571514,0.0002176378,0.00003699414,0.0004810432],"genre_scores_gemma":[0.9956334,0.0005736168,0.0005837877,0.00006004027,0.00001401283,0.00004708154,0.0005064002,0.0000128434,0.00256883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149182,"threshold_uncertainty_score":0.00384438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409388076093695,"score_gpt":0.2614433967887947,"score_spread":0.2473495160278578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}