{"id":"W2804323293","doi":"10.1371/journal.pbio.2005130","title":"High-dimensional single-cell phenotyping reveals extensive haploinsufficiency","year":2018,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Haploinsufficiency; Biology; Phenotype; Genetics; Gene; Mutation; Mutant; Gene regulatory network; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268075,0.0002356926,0.000261898,0.00006304436,0.000180388,0.00001640524,0.0002654169,0.0003019529,0.0001169506],"category_scores_gemma":[0.0001389529,0.0002123657,0.0000991614,0.0001071515,0.0003863859,0.000003905912,0.000119188,0.000125261,0.0001506432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001963989,"about_ca_system_score_gemma":0.00006298858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004001433,"about_ca_topic_score_gemma":0.00002578423,"domain_scores_codex":[0.9984318,0.0001041458,0.0003038345,0.0006094524,0.00009256226,0.0004582187],"domain_scores_gemma":[0.9990627,0.00003174981,0.0001137031,0.0003915017,0.0002915544,0.0001088198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347974,0.0003771486,0.001349165,0.00001200757,0.00003922462,0.000002847977,0.00004852555,0.000008516137,0.9955399,0.0003316966,0.0009867074,0.00116945],"study_design_scores_gemma":[0.000906529,0.001893628,0.0007135802,0.00002447728,0.00003994543,0.00001922543,0.0000232765,0.000266973,0.987978,0.0008065224,0.006913521,0.0004143546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931011,0.0006256507,0.002935087,0.0001932786,0.0007432264,0.0001783394,0.00003651826,0.00004406323,0.002142717],"genre_scores_gemma":[0.993069,0.00003238978,0.003298936,0.001739667,0.001087787,0.00001095089,0.0001803536,0.00003626817,0.0005446554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007561947,"threshold_uncertainty_score":0.8660021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161670907481834,"score_gpt":0.2305975454063227,"score_spread":0.2089808363315044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}