{"id":"W2804341071","doi":"10.1021/acs.jnatprod.8b00218","title":"Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from <i>Narcissus</i> and <i>Galanthus</i> sp.: De Novo Total Synthesis of 2-<i>epi</i>-Narciclasine","year":2018,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vineland Research and Innovation Centre; Brock University; McMaster University","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; Ontario Partnership for Innovation and Commercialization; Brock University; Canada Research Chairs; TDC Research; Stanley Medical Research Institute; Canada Foundation for Innovation; Teva Pharmaceutical Industries","keywords":"Amaryllidaceae Alkaloids; Stereochemistry; Epimer; Chemistry; Lycorine; Total synthesis; Amaryllidaceae; Natural product; Semisynthesis; Alkaloid; Biology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000496302,0.0003399708,0.0009440145,0.0001243913,0.0001014466,0.00004512262,0.0003255818,0.0002126413,0.0002054711],"category_scores_gemma":[0.004045073,0.000272895,0.0001624449,0.0002394185,0.0007666373,0.0003263155,0.0001435587,0.0003831452,0.000002028722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006544725,"about_ca_system_score_gemma":0.0001438268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006071051,"about_ca_topic_score_gemma":0.000005009721,"domain_scores_codex":[0.9975869,0.00007697165,0.001050691,0.0004052226,0.0005249003,0.0003552874],"domain_scores_gemma":[0.9961683,0.001549618,0.001058415,0.0003719566,0.0006461944,0.0002055059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00060579,0.0001941395,0.01454623,0.0003656521,0.0002639198,0.00001904368,0.000202538,0.000001019885,0.972245,0.00001543964,0.0009599546,0.01058132],"study_design_scores_gemma":[0.0004924887,0.00005406103,0.005796652,0.001134804,0.000371648,0.0004154509,0.0001625338,0.00006053544,0.989962,0.0002048556,0.00106914,0.0002758608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916046,0.005971396,0.00001216406,0.001370619,0.0001744631,0.00007594968,0.0001469335,0.00001640905,0.0006275047],"genre_scores_gemma":[0.9939082,0.0007589511,0.004321117,0.00005936356,0.0008245618,0.000002585185,0.000003543295,0.00003521194,0.00008647842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01771702,"threshold_uncertainty_score":0.9999723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006467517558008821,"score_gpt":0.2144734313280763,"score_spread":0.2080059137700675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}