{"id":"W2804341071","doi":"10.1021/acs.jnatprod.8b00218","title":"Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from <i>Narcissus</i> and <i>Galanthus</i> sp.: De Novo Total Synthesis of 2-<i>epi</i>-Narciclasine","year":2018,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vineland Research and Innovation Centre; Brock University; McMaster University","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; Ontario Partnership for Innovation and Commercialization; Brock University; Canada Research Chairs; TDC Research; Stanley Medical Research Institute; Canada Foundation for Innovation; Teva Pharmaceutical Industries","keywords":"Amaryllidaceae Alkaloids; Stereochemistry; Epimer; Chemistry; Lycorine; Total synthesis; Amaryllidaceae; Natural product; Semisynthesis; Alkaloid; Biology; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008485448,0.0006688862,0.0002930849,0.0003401735,0.0001868736,0.0001998943,0.0002142879,0.000192579,0.0007647098],"category_scores_gemma":[0.0001227841,0.0001713871,0.0003285169,0.0003311665,0.0001376205,0.0002797217,0.0003715572,0.0005686504,0.000717379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838403,"about_ca_system_score_gemma":0.0002996894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005681295,"about_ca_topic_score_gemma":0.001307006,"domain_scores_codex":[0.999946,0.00000569744,0.000006642548,0.00001473539,0.00001534941,0.00001156926],"domain_scores_gemma":[0.9999241,0.000007107416,0.00001872969,0.00001395844,0.00001762772,0.00001852519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002125361,0.00001328962,0.00008060796,0.00009417243,0.000009703441,0.00008595629,0.00002910043,0.00009827681,0.9936855,0.00009166646,0.00004147768,0.005749041],"study_design_scores_gemma":[0.00002352838,0.0003529838,0.004384599,0.00001839071,0.00005577213,0.0004258172,0.00004641967,0.00031095,0.9797047,0.0002283308,0.01442984,0.00001868501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9185727,0.01177259,0.0493191,0.0003305898,0.0001461696,0.0004538452,0.003013632,0.0005290458,0.0158623],"genre_scores_gemma":[0.9479807,0.008837292,0.03302146,0.0001598702,0.00003895642,0.0001983884,0.003485939,0.0001319409,0.006145483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007647098,"threshold_uncertainty_score":0.002558172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006467517558008821,"score_gpt":0.2144734313280763,"score_spread":0.2080059137700675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}