{"id":"W2804473699","doi":"10.1111/jdi.12867","title":"Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes","year":2018,"lang":"en","type":"article","venue":"Journal of Diabetes Investigation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Fundamental Research Funds for the Central Universities; National Science and Technology Infrastructure Program; Natural Science Foundation of Hunan Province; China Scholarship Council; Central South University; Ministry of Education of the People's Republic of China; National Natural Science Foundation of China","keywords":"Chromatin immunoprecipitation; Acetylation; Glutamate decarboxylase; Histone; Molecular biology; Histone H3; Biology; Epigenetics; Promoter; Gene expression; Gene; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003997609,0.0001716332,0.0002337213,0.0002234012,0.00005900678,0.00003582118,0.00007287052,0.0001497613,0.000002866053],"category_scores_gemma":[0.0003919784,0.0001437213,0.0000226776,0.0005356506,0.0001599287,0.00008626729,0.00002173872,0.0001061145,5.765945e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001377182,"about_ca_system_score_gemma":0.0001446834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008950565,"about_ca_topic_score_gemma":0.00006828662,"domain_scores_codex":[0.9987865,0.000118543,0.0003749814,0.0002347695,0.0002431504,0.0002420752],"domain_scores_gemma":[0.9986007,0.00002057275,0.0006069919,0.000114474,0.0005885459,0.00006874069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009473116,0.00008904674,0.7118769,0.00001383048,0.00006799508,1.42279e-7,0.0001309858,0.0001272425,0.2866271,8.781323e-7,0.00004140301,0.0009297709],"study_design_scores_gemma":[0.002063169,0.001036022,0.6213912,0.000263807,0.00003272449,7.730421e-8,0.00004334961,0.0003843477,0.3745271,0.00008262428,0.00002564255,0.0001499521],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999225,0.0002664461,0.000005885662,0.0001588505,0.00009879444,0.0002234124,0.000004478126,0.000007238861,0.000009848814],"genre_scores_gemma":[0.9991687,0.00006106257,0.0002080119,0.0001984076,0.0000762766,0.000004977504,0.0002448771,0.00002508013,0.00001262925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09048574,"threshold_uncertainty_score":0.5860786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00590273267627653,"score_gpt":0.220556126914653,"score_spread":0.2146533942383765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}