{"id":"W2804473699","doi":"10.1111/jdi.12867","title":"Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes","year":2018,"lang":"en","type":"article","venue":"Journal of Diabetes Investigation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Fundamental Research Funds for the Central Universities; National Science and Technology Infrastructure Program; Natural Science Foundation of Hunan Province; China Scholarship Council; Central South University; Ministry of Education of the People's Republic of China; National Natural Science Foundation of China","keywords":"Chromatin immunoprecipitation; Acetylation; Glutamate decarboxylase; Histone; Molecular biology; Histone H3; Biology; Epigenetics; Promoter; Gene expression; Gene; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319563,0.0003305263,0.0003099727,0.0005421413,0.0002990456,0.0003402087,0.0001511464,0.0003102858,0.002022764],"category_scores_gemma":[0.0003206512,0.0001655639,0.0002968235,0.0006458527,0.0001520092,0.0001251944,0.0001624102,0.0003687483,0.0001444904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001541936,"about_ca_system_score_gemma":0.00008726768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008813218,"about_ca_topic_score_gemma":0.0009823032,"domain_scores_codex":[0.9998498,0.00002271283,0.00001840288,0.0000607592,0.0000205842,0.00002774396],"domain_scores_gemma":[0.9997031,0.00004665315,0.0001548608,0.00001318055,0.00002486965,0.00005727184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009188973,0.00004980317,0.9837613,0.00004084774,0.00008270695,0.0004532008,0.00006907947,0.00003888901,0.01193749,0.00001129454,0.0001029401,0.002533478],"study_design_scores_gemma":[0.00001101958,0.0001213988,0.9974776,0.00000467677,0.00006074311,0.001002362,0.00007056976,0.0001052903,0.0009925847,0.00001938016,0.0001319039,0.000002618641],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988844,0.0005275976,0.0001652656,0.00002491774,0.000008030483,0.000003866518,0.0001958851,0.00000689349,0.0001832814],"genre_scores_gemma":[0.9992738,0.000135226,0.0001497269,0.0000240177,0.0000118187,0.000005205424,0.0002027154,0.000002043951,0.0001953958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022764,"threshold_uncertainty_score":0.006766856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00590273267627653,"score_gpt":0.220556126914653,"score_spread":0.2146533942383765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}