{"id":"W2804492207","doi":"10.1016/j.cllc.2018.05.002","title":"Rationale and Protocol for a Canadian Multicenter Phase II Randomized Trial Assessing Selective Metabolically Adaptive Radiation Dose Escalation in Locally Advanced Non–small-cell Lung Cancer (NCT02788461)","year":2018,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cancer Care Ontario; Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto","funders":"","keywords":"Medicine; Lung cancer; Randomized controlled trial; Radiation therapy; Oncology; Population; Internal medicine; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001103918,0.000347419,0.001141818,0.0001970002,0.0002916965,0.00007214298,0.0000887634,0.0002790689,0.0001948508],"category_scores_gemma":[0.0005878383,0.0002781267,0.0002983311,0.0003047705,0.0002201066,0.0002980191,0.00003649068,0.0003242321,0.00000177446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00153614,"about_ca_system_score_gemma":0.003307947,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.008685909,"about_ca_topic_score_gemma":0.05529467,"domain_scores_codex":[0.9969117,0.000298737,0.001179059,0.0008252296,0.0002745221,0.0005107626],"domain_scores_gemma":[0.9971324,0.00099776,0.0004824269,0.0002403802,0.0006771967,0.0004698026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8889937,0.002447056,0.02688992,0.0003053192,0.0008249948,0.000009593658,0.0008647572,0.0001634018,0.0001186767,0.00007887207,0.004061251,0.0752424],"study_design_scores_gemma":[0.8675656,0.002614895,0.01330226,0.0008079436,0.001187452,7.639218e-7,0.00003154502,0.1087507,0.0006476438,0.00004553124,0.004734763,0.0003109282],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"empirical","genre_scores_codex":[0.4732382,0.0009912013,0.004430083,0.005068952,0.0013588,0.5135993,0.000234695,0.00007180373,0.001007019],"genre_scores_gemma":[0.5012233,0.000154648,0.003244056,0.001743972,0.001577419,0.4915773,0.00006931248,0.00005243911,0.0003575047],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.1085873,"threshold_uncertainty_score":0.9999671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03836284371604642,"score_gpt":0.4455259397304963,"score_spread":0.4071630960144498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}