{"id":"W2804559696","doi":"10.1161/circulationaha.118.035202","title":"Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation","year":2018,"lang":"en","type":"article","venue":"Circulation","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":641,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute","keywords":"Medicine; Inflammasome; Atrial fibrillation; Cardiology; Internal medicine; Signal transduction; Cell biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446381,0.0001236929,0.0001100337,0.00005337052,0.0001480704,0.00003521641,0.00007582741,0.0001473845,0.00003804103],"category_scores_gemma":[0.0001100063,0.0001336689,0.0001464978,0.0001174841,0.00006297498,0.00001434167,0.00003662915,0.00004127801,0.00006745132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001871494,"about_ca_system_score_gemma":0.00005474581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000734518,"about_ca_topic_score_gemma":0.000005724402,"domain_scores_codex":[0.9991429,0.00004956451,0.0002175757,0.000269141,0.0001270282,0.0001937227],"domain_scores_gemma":[0.9994293,0.000007189364,0.0001022536,0.0002502918,0.0001796447,0.0000313282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008543497,0.000002134876,0.00607468,0.000008603779,0.00005251652,2.309714e-7,0.0001702004,0.001649346,0.9817582,0.00006331919,0.00002947206,0.01010583],"study_design_scores_gemma":[0.000823441,0.0001364759,0.0276545,0.00001617063,0.00003384834,0.000004039948,0.00005849717,0.001050838,0.9601471,0.0002824106,0.0095211,0.0002715612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881116,0.0004296952,0.009102419,0.00003551249,0.0003393308,0.0002504618,0.000002280176,0.00002943152,0.001699309],"genre_scores_gemma":[0.9969922,0.0000229222,0.0001841926,0.00002840245,0.002418714,0.000004285829,0.0002551639,0.00002084501,0.00007332648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02161112,"threshold_uncertainty_score":0.545086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00936081521459657,"score_gpt":0.2398318216469826,"score_spread":0.2304710064323861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}