{"id":"W2804575948","doi":"10.1038/s41588-018-0127-7","title":"Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error","year":2018,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Ophthalmology and Visual Impairment Studies","field":"Medicine","cited_by":378,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Medical Research Council; National Health and Medical Research Council; Alcon Research Institute; Stichting Nederlands Oogheelkundig Onderzoek; Abbott Diabetes Care; National Institutes of Health; Westmead Millennium Institute for Medical Research; Moorfields Eye Charity; Medical Research Council; Tartu Ülikool; State Government of Victoria; Diabetes UK; Ohio Lions Eye Research Foundation; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; Tampereen Yliopisto; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; ZonMw; Moorfields Eye Hospital NHS Foundation Trust; Macula Society; Northwest Regional Development Agency; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Flinders University; European Commission; European Regional Development Fund; King's College London; Singapore Eye Research Institute; Jyväskylän Yliopisto; Wellcome Trust; National University of Singapore; Landelijke Stichting voor Blinden en Slechtzienden; Cancer Research UK; Turun Yliopistollinen Keskussairaala; Stichting Steunfonds Uitzicht; Pfizer Australia; Horizon 2020 Framework Programme; Turun Yliopisto; Hrvatska Zaklada za Znanost; Scottish Government; QIMR Berghofer Medical Research Institute; Bundesministerium für Bildung und Forschung; British Heart Foundation; Case Western Reserve University; National Eye Institute; National Institute for Health and Care Research; Pfizer; International Glaucoma Association; Institute of Genetics; Agence Nationale de la Recherche; Biomedical Research Council; Ophthalmic Research Institute of Australia; Oogfonds; European Foundation for the Study of Diabetes; American Health Assistance Foundation; Research to Prevent Blindness","keywords":"Biology; Retina; Retinal pigment epithelium; Genetic association; Genome-wide association study; Retinal; Extracellular matrix; Genetics; Blindness; Refractive error; Cell biology; Neuroscience; Computational biology; Gene; Single-nucleotide polymorphism; Genotype; Eye disease; Optometry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002842721,0.001149914,0.002614094,0.001257258,0.0002749017,0.001510672,0.001180733,0.001516863,0.004086383],"category_scores_gemma":[0.009270268,0.0004154819,0.008113711,0.002574863,0.000313696,0.0008015422,0.0007842541,0.001541103,0.0003003631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004461565,"about_ca_system_score_gemma":0.001273128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005373096,"about_ca_topic_score_gemma":0.009995987,"domain_scores_codex":[0.9983596,0.0005576277,0.0003556515,0.0004131636,0.0002058995,0.0001080625],"domain_scores_gemma":[0.994073,0.004816002,0.000521814,0.0002234106,0.0002767385,0.00008914874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005064749,0.000127056,0.178773,0.1049479,0.40453,0.001945131,0.0004145369,0.001590867,0.002510972,0.003500195,0.01421361,0.282382],"study_design_scores_gemma":[0.0007295986,0.0004670872,0.1707394,0.01619114,0.7560059,0.001890274,0.0003980701,0.0007120189,0.001001996,0.007019674,0.04472379,0.0001210362],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01132288,0.9848782,0.0007576541,0.001225307,0.0003024749,0.00001326041,0.0008149558,0.00001807803,0.000667225],"genre_scores_gemma":[0.2818563,0.7095913,0.002173019,0.002698055,0.0008374765,0.00005339011,0.001854666,0.00003179583,0.0009040046],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005373096,"threshold_uncertainty_score":0.01503396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.111678725481876,"score_gpt":0.4318228611241954,"score_spread":0.3201441356423194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}