{"id":"W2804575948","doi":"10.1038/s41588-018-0127-7","title":"Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error","year":2018,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Ophthalmology and Visual Impairment Studies","field":"Medicine","cited_by":378,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Medical Research Council; National Health and Medical Research Council; Alcon Research Institute; Stichting Nederlands Oogheelkundig Onderzoek; Abbott Diabetes Care; National Institutes of Health; Westmead Millennium Institute for Medical Research; Moorfields Eye Charity; Medical Research Council; Tartu Ülikool; State Government of Victoria; Diabetes UK; Ohio Lions Eye Research Foundation; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; Tampereen Yliopisto; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; ZonMw; Moorfields Eye Hospital NHS Foundation Trust; Macula Society; Northwest Regional Development Agency; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Flinders University; European Commission; European Regional Development Fund; King's College London; Singapore Eye Research Institute; Jyväskylän Yliopisto; Wellcome Trust; National University of Singapore; Landelijke Stichting voor Blinden en Slechtzienden; Cancer Research UK; Turun Yliopistollinen Keskussairaala; Stichting Steunfonds Uitzicht; Pfizer Australia; Horizon 2020 Framework Programme; Turun Yliopisto; Hrvatska Zaklada za Znanost; Scottish Government; QIMR Berghofer Medical Research Institute; Bundesministerium für Bildung und Forschung; British Heart Foundation; Case Western Reserve University; National Eye Institute; National Institute for Health and Care Research; Pfizer; International Glaucoma Association; Institute of Genetics; Agence Nationale de la Recherche; Biomedical Research Council; Ophthalmic Research Institute of Australia; Oogfonds; European Foundation for the Study of Diabetes; American Health Assistance Foundation; Research to Prevent Blindness","keywords":"Biology; Retina; Retinal pigment epithelium; Genetic association; Genome-wide association study; Retinal; Extracellular matrix; Genetics; Blindness; Refractive error; Cell biology; Neuroscience; Computational biology; Gene; Single-nucleotide polymorphism; Genotype; Eye disease; Optometry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007763585,0.0007295575,0.004933515,0.0005777968,0.0003056755,0.00003496499,0.0002579062,0.002688687,0.000259699],"category_scores_gemma":[0.001089317,0.0004969889,0.004212125,0.0008923213,0.00003845089,0.00004602731,0.000116798,0.001240897,0.0001647785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005462555,"about_ca_system_score_gemma":0.0003058133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002841212,"about_ca_topic_score_gemma":0.000006041506,"domain_scores_codex":[0.9968067,0.0003040954,0.000841727,0.0009027625,0.0005963526,0.0005482932],"domain_scores_gemma":[0.9958386,0.001206381,0.001271766,0.0005997497,0.0009139239,0.0001695905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001421266,0.000668124,0.0006526412,0.006410952,0.9833921,0.00007730039,0.0005339173,0.000001236441,0.00002399493,0.00002826135,0.00647048,0.001598827],"study_design_scores_gemma":[0.0002339163,0.0008746362,0.0003467806,0.0001416452,0.4641454,0.000009096025,0.00001486545,0.000001251627,0.00008674443,0.00006761323,0.5337819,0.0002961296],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001836898,0.9936419,0.00003297169,0.0009887321,0.0005623214,0.002260575,0.0001305447,0.00005655186,0.0004894861],"genre_scores_gemma":[0.004266741,0.9814746,0.001849682,0.0009209661,0.001334441,0.0004363153,0.0006101058,0.0001101372,0.008996968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5273114,"threshold_uncertainty_score":0.9997482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.111678725481876,"score_gpt":0.4318228611241954,"score_spread":0.3201441356423194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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