{"id":"W2804637321","doi":"10.1155/2018/6463807","title":"Geranylgeraniol Prevents Statin‐Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy","year":2018,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministerstwo Edukacji i Nauki; School of Medicine, New York University; Narodowe Centrum Nauki; York University","keywords":"Geranylgeraniol; Viability assay; Statin; Mevalonate pathway; Myogenesis; Chemistry; Fluvastatin; Pharmacology; Atorvastatin; Mevalonic acid; Myocyte; Biology; Cell biology; Biochemistry; Farnesol; Simvastatin; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000149892,0.0004623611,0.000573278,0.0002318376,0.0002026827,0.0002077083,0.0002115743,0.0003284959,0.0008313927],"category_scores_gemma":[0.00008509596,0.0001611861,0.0003649738,0.0001665624,0.000233704,0.0001990064,0.0002375096,0.0004898954,0.0002391023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002010091,"about_ca_system_score_gemma":0.0003444505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356508,"about_ca_topic_score_gemma":0.004425688,"domain_scores_codex":[0.9998662,0.00003012048,0.00001949333,0.00002049225,0.00003101957,0.00003261217],"domain_scores_gemma":[0.9999191,0.00001099767,0.00002510776,0.00001119723,0.00001406741,0.00001948347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004127985,0.00005881473,0.0001227285,0.00008822823,0.00001048377,0.00006233658,0.00002245255,0.00005314593,0.998168,0.00002803384,0.00003215569,0.0009408319],"study_design_scores_gemma":[0.00003492217,0.001083067,0.003969155,0.00001040589,0.00002808551,0.0001490893,0.00004748223,0.000310837,0.992935,0.00001945121,0.001406685,0.000005851953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955983,0.002379512,0.0007187412,0.00009845725,0.00002598129,0.00002961528,0.0002297259,0.00005651137,0.0008633704],"genre_scores_gemma":[0.9929637,0.002193398,0.001583363,0.00008147279,0.0000116348,0.00006936877,0.0005035193,0.00001658077,0.002577034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356508,"threshold_uncertainty_score":0.002781272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486738415984791,"score_gpt":0.2966439226891419,"score_spread":0.271776538529294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}