{"id":"W2804637321","doi":"10.1155/2018/6463807","title":"Geranylgeraniol Prevents Statin‐Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy","year":2018,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministerstwo Edukacji i Nauki; School of Medicine, New York University; Narodowe Centrum Nauki; York University","keywords":"Geranylgeraniol; Viability assay; Statin; Mevalonate pathway; Myogenesis; Chemistry; Fluvastatin; Pharmacology; Atorvastatin; Mevalonic acid; Myocyte; Biology; Cell biology; Biochemistry; Farnesol; Simvastatin; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006707339,0.0003695597,0.0006599268,0.0001550296,0.0001948351,0.00001886238,0.00009197642,0.0001717197,0.0006662817],"category_scores_gemma":[0.0001311401,0.0002942743,0.00006412342,0.0003009131,0.0005483939,0.0003073973,0.00008359156,0.0003808814,0.0000198482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009599455,"about_ca_system_score_gemma":0.00008303378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004903223,"about_ca_topic_score_gemma":0.00005794658,"domain_scores_codex":[0.9976318,0.0003370668,0.0004790961,0.0007014151,0.0004539096,0.0003967337],"domain_scores_gemma":[0.9988388,0.0001483543,0.0002157965,0.0003832238,0.0001535832,0.0002601822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001049343,0.0007520911,0.005492233,0.0003427992,0.0002173807,0.0003007476,0.01527702,0.000001979552,0.9495816,0.0002774344,0.0001842048,0.02652315],"study_design_scores_gemma":[0.008498213,0.002232083,0.1526751,0.0005521689,0.0002437439,0.00002049827,0.001265554,0.0008471819,0.8287073,0.003581215,0.0009563864,0.000420567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872899,0.002426745,0.006716814,0.0003340555,0.0001571708,0.001561717,0.00002660631,0.00005770312,0.001429266],"genre_scores_gemma":[0.9971533,0.0006166136,0.0005716101,0.000716166,0.0004054851,0.00008326364,0.00004911163,0.00003349731,0.000370923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1471828,"threshold_uncertainty_score":0.9999509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486738415984791,"score_gpt":0.2966439226891419,"score_spread":0.271776538529294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}