{"id":"W2804712568","doi":"10.1186/s12933-018-0682-3","title":"Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk","year":2018,"lang":"en","type":"article","venue":"Cardiovascular Diabetology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Eli Lilly and Company","keywords":"Linagliptin; Medicine; Kidney disease; Placebo; Randomized controlled trial; Internal medicine; Hazard ratio; Renal function; Population; Type 2 diabetes; Clinical trial; Diabetes mellitus; Confidence interval; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.009364064,0.0005741374,0.005062974,0.0002802612,0.0001969813,0.00005029689,0.0001696268,0.000259251,0.000008597252],"category_scores_gemma":[0.0008359764,0.0003349115,0.001042758,0.0003889128,0.001216137,0.0001108489,0.0002490922,0.0004333305,0.000002420001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006000027,"about_ca_system_score_gemma":0.0001300177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006756398,"about_ca_topic_score_gemma":0.00002302472,"domain_scores_codex":[0.9929212,0.003336994,0.001385839,0.001017171,0.0008103774,0.0005284659],"domain_scores_gemma":[0.9965549,0.0009126968,0.0004442884,0.001210555,0.0006744681,0.0002030508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5899559,0.0005458632,0.3655887,0.00008110827,0.03567559,0.00002618181,0.0001104614,0.0001316012,0.000001960051,0.0000139654,0.000007141526,0.007861487],"study_design_scores_gemma":[0.7717736,0.003778076,0.1988971,0.00009302281,0.02422359,0.000006117152,0.00004249263,0.0002810972,0.00003731571,0.000009267234,0.0005518709,0.0003063834],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976454,0.00501639,0.001807294,0.00005911669,0.0003390581,0.01624509,0.00002036914,0.0000307387,0.00002797127],"genre_scores_gemma":[0.9964443,0.0008383655,0.001472514,0.00006825304,0.0003315374,0.0006480834,0.000096695,0.00006352351,0.00003671421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1818177,"threshold_uncertainty_score":0.9999103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964555084014042,"score_gpt":0.2574619648360832,"score_spread":0.2378164139959428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}