{"id":"W2804796581","doi":"10.1038/s41467-018-04261-1","title":"A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; National Institutes of Health; Case Western Reserve University; University of Pittsburgh; Augusta University; University of Cincinnati; Canadian Institute for Advanced Research","keywords":"Opsin; Rhodopsin; Retinal degeneration; Retinitis pigmentosa; Retinal; Cell biology; Biology; Visual phototransduction; Retina; Retinaldehyde; Mutant; Biochemistry; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101201,0.00007225543,0.00006567453,0.00002767707,0.0001424866,0.00001132851,0.0002579383,0.000158726,0.000003360609],"category_scores_gemma":[0.00007388886,0.0000688023,0.00003302565,0.00006049875,0.00008894556,0.000003130832,0.0001070692,0.00008066736,6.393937e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003213142,"about_ca_system_score_gemma":0.00004687441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003286754,"about_ca_topic_score_gemma":0.0001059532,"domain_scores_codex":[0.9995884,0.00002469519,0.0001179814,0.0001345935,0.00004858898,0.00008568311],"domain_scores_gemma":[0.9992959,0.00001054787,0.00006365223,0.0003538476,0.000251168,0.00002492092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001024093,0.00007321842,0.000196459,0.000004393578,0.00001978658,1.596838e-8,0.00005770552,0.000001046832,0.9958749,0.002197676,0.0004965036,0.000975837],"study_design_scores_gemma":[0.001443815,0.0005169735,0.00856608,0.00001427995,0.00002168038,0.000008851972,0.00006785899,0.001285226,0.9512641,0.0001122766,0.03649433,0.0002044828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797014,0.01012273,0.007083062,0.001666083,0.0000690446,0.0003428494,0.00002721129,0.000007642018,0.000979991],"genre_scores_gemma":[0.9771458,0.00139036,0.02060152,0.0002530162,0.00006587675,0.00003629874,0.00034174,0.000009840004,0.0001555807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04461081,"threshold_uncertainty_score":0.2805676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203503655527853,"score_gpt":0.2849866285887058,"score_spread":0.2646362630359205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}