{"id":"W2804813184","doi":"10.1158/1541-7786.mcr-17-0772","title":"Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell-Cycle Kinetics","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"Telomerase; Telomere; DNA damage; Cell cycle; Telomerase reverse transcriptase; Biology; Cell biology; Molecular biology; Cell cycle checkpoint; Ribonucleoprotein; Cell division; DNA; Cell; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203678,0.000306477,0.00032024,0.0002346919,0.00009955415,0.0002997289,0.0002815982,0.0002192336,0.001597686],"category_scores_gemma":[0.0001092378,0.0001047099,0.0001825148,0.0002583587,0.000115679,0.0001653512,0.0001228647,0.0006369784,0.0003720593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002687869,"about_ca_system_score_gemma":0.0001572541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004204359,"about_ca_topic_score_gemma":0.0005149753,"domain_scores_codex":[0.9998658,0.00001492209,0.0000213754,0.00003431019,0.000030662,0.00003296709],"domain_scores_gemma":[0.9998821,0.0000314598,0.00002995623,0.00001879488,0.00001437553,0.00002330777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003387005,0.0001262989,0.0001618202,0.00002897867,0.000005670294,0.00001998873,0.00001088802,0.0001088107,0.9972526,0.00005807903,0.00007791767,0.001810202],"study_design_scores_gemma":[0.00001223084,0.0003055075,0.0008285948,0.000002101794,0.000006880832,0.00002161176,0.000005787884,0.0005588059,0.9973792,0.000009311426,0.0008680966,0.000001831753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931054,0.002337404,0.001282821,0.00007624181,0.00008254452,0.00003471149,0.00101052,0.0001404878,0.001929992],"genre_scores_gemma":[0.9939885,0.0008970397,0.0009490389,0.00004556321,0.00001738209,0.00005912619,0.0008832022,0.00002397592,0.003136173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597686,"threshold_uncertainty_score":0.005344748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244226522616747,"score_gpt":0.3501397863890185,"score_spread":0.3176975211628511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}