{"id":"W2804813184","doi":"10.1158/1541-7786.mcr-17-0772","title":"Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell-Cycle Kinetics","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"Telomerase; Telomere; DNA damage; Cell cycle; Telomerase reverse transcriptase; Biology; Cell biology; Molecular biology; Cell cycle checkpoint; Ribonucleoprotein; Cell division; DNA; Cell; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005259152,0.0002403316,0.0003201475,0.0003983591,0.000212357,0.00009204753,0.0001120205,0.0001139326,0.0003855299],"category_scores_gemma":[0.00007154351,0.0001942189,0.00005779587,0.0008968632,0.0007435898,0.000112927,0.00007063637,0.0004556572,0.00004128463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687045,"about_ca_system_score_gemma":0.0003287831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007013214,"about_ca_topic_score_gemma":0.0002193067,"domain_scores_codex":[0.9970014,0.0002053516,0.0002601036,0.0005753047,0.001139917,0.0008179349],"domain_scores_gemma":[0.9982219,0.00007356578,0.00005075778,0.0004835206,0.0005949289,0.0005753112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007475298,0.0002268797,0.0008611624,0.0002546819,0.00004895073,0.0007938473,0.001076829,0.00001020203,0.9892067,0.00002174434,0.001023673,0.005727803],"study_design_scores_gemma":[0.00234946,0.002306373,0.009266744,0.0003452739,0.00006095597,0.0000631074,0.0003174752,0.0001911294,0.981661,0.00006549583,0.003120256,0.0002527174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928884,0.001795228,0.0006499907,0.001665566,0.00004603069,0.0007886643,0.00003584493,0.00005407133,0.002076188],"genre_scores_gemma":[0.9975151,0.000529436,0.0006418877,0.0006374553,0.0001706558,0.00007105294,0.00002678961,0.00006731522,0.0003402514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008405582,"threshold_uncertainty_score":0.7920017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244226522616747,"score_gpt":0.3501397863890185,"score_spread":0.3176975211628511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}