{"id":"W2804849469","doi":"10.1016/j.dnarep.2018.05.002","title":"Persistent 3′-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3′-phosphatase","year":2018,"lang":"en","type":"article","venue":"DNA repair","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Calgary","funders":"National Cancer Institute; Canadian Institutes of Health Research; Alberta Cancer Foundation; U.S. Department of Health and Human Services","keywords":"Phosphatase; Biology; DNA repair; DNA; HeLa; Dephosphorylation; Molecular biology; Neocarzinostatin; Kinase; Bromodeoxyuridine; Biochemistry; Phosphate; DNA damage; Phosphorylation; Cell; Cell growth","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003126796,0.0006164984,0.0004460785,0.00028982,0.0001669457,0.0005188232,0.000470339,0.0005185236,0.002084625],"category_scores_gemma":[0.0003731976,0.0004325148,0.0003268724,0.0002317509,0.0004991678,0.000439814,0.0003336107,0.00110417,0.0006033133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003328444,"about_ca_system_score_gemma":0.0003981396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013329,"about_ca_topic_score_gemma":0.0006444139,"domain_scores_codex":[0.9997107,0.00004522088,0.00003523607,0.00005790981,0.00008901129,0.00006176472],"domain_scores_gemma":[0.9995728,0.00009490136,0.00008356044,0.00009936617,0.000064821,0.00008461811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002440228,0.00001664336,0.0001226972,0.00002259246,0.000004945519,0.00005120047,0.00001257026,0.00004266731,0.998901,0.0001122496,0.0000108016,0.0004585079],"study_design_scores_gemma":[0.000009855331,0.0001449296,0.001052078,0.000002295141,0.00001324658,0.0001477617,0.00000896416,0.0002916375,0.9978416,0.00002750855,0.0004581112,0.0000020601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901675,0.001753962,0.005929528,0.0001011548,0.00006032038,0.00002600922,0.0004993634,0.0001373288,0.001324865],"genre_scores_gemma":[0.9945986,0.0003218095,0.001777675,0.00002283897,0.00001044365,0.00003025726,0.0007488719,0.00003209312,0.002457436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002084625,"threshold_uncertainty_score":0.006973743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157716944551749,"score_gpt":0.2489433036584887,"score_spread":0.2373661342129712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}