{"id":"W2804899347","doi":"10.1139/bcb-2018-0004","title":"mTOR signalling: jack-of-all-trades","year":2018,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Dalhousie University","funders":"University of Toronto; Dalhousie University","keywords":"PI3K/AKT/mTOR pathway; Biology; Mechanistic target of rapamycin; RPTOR; mTORC2; Signalling; Kinase; Cell biology; Autophagy; Signal transduction; mTORC1; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004680422,0.0007870984,0.001067681,0.001562239,0.0003827237,0.001652392,0.0008308179,0.001196342,0.00535997],"category_scores_gemma":[0.000584976,0.0002437025,0.0004618052,0.001365725,0.0005918813,0.002121015,0.001080223,0.002649363,0.004373074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006708385,"about_ca_system_score_gemma":0.0007501349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004408659,"about_ca_topic_score_gemma":0.0008369584,"domain_scores_codex":[0.9998125,0.00002470966,0.00002901503,0.00004797129,0.0000607289,0.00002500139],"domain_scores_gemma":[0.9998485,0.00005224967,0.00002278352,0.000007245875,0.00004165595,0.00002758552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001126089,0.00003818576,0.0001641297,0.007797662,0.000093694,0.0003380813,0.00005969643,0.000267447,0.00280803,0.01338892,0.05750927,0.9174224],"study_design_scores_gemma":[0.000007750383,0.00002938084,0.0001922162,0.000816932,0.00003324342,0.0008092094,0.00002688689,0.00005400796,0.0005046463,0.002406475,0.9951089,0.00001033995],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002031763,0.9945616,0.0003892573,0.001127557,0.0009690943,0.000006148936,0.00003990985,0.00002729653,0.002675902],"genre_scores_gemma":[0.001728794,0.993647,0.0002961755,0.0007220618,0.0006211122,0.000008083282,0.00007797446,0.000007810562,0.002890893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00535997,"threshold_uncertainty_score":0.01793092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0351789042895496,"score_gpt":0.3129830484434548,"score_spread":0.2778041441539052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}