{"id":"W2804899379","doi":"10.1002/anie.201803254","title":"Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; Kelowna General Hospital; University of British Columbia; Simon Fraser University","funders":"Canadian Glycomics Network; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Serine; In vivo; Transferase; N-Acetylglucosamine; Threonine; Glycosylation; Biochemistry; Enzyme; Leptin; Chemistry; Biology; Nutrient sensing; In vitro; Cell biology; Signal transduction; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644038,0.0006349918,0.0002717452,0.0002077757,0.0001338583,0.0002163317,0.0001949763,0.0002772154,0.001335527],"category_scores_gemma":[0.0001359504,0.0001640876,0.0002637815,0.000178529,0.0002715246,0.0002324112,0.0001216618,0.0006733914,0.0002925179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002794109,"about_ca_system_score_gemma":0.0002965372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004575239,"about_ca_topic_score_gemma":0.0009672955,"domain_scores_codex":[0.9998713,0.00003424441,0.00001148277,0.00002671774,0.00003030598,0.00002607026],"domain_scores_gemma":[0.9998674,0.00003043124,0.00004536539,0.00001652367,0.000009744728,0.00003044367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002059969,0.00003627223,0.00006599283,0.0000189842,0.000004507284,0.00002099218,0.000004118027,0.00002941499,0.9988093,0.00006548189,0.00001903552,0.0007198668],"study_design_scores_gemma":[0.00001321787,0.0004695311,0.0006179656,0.000002016931,0.000008220163,0.0000695532,0.000005073636,0.0001479667,0.9980631,0.00001669219,0.0005852676,0.000001378801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851022,0.003106036,0.008113595,0.0001762194,0.00009086936,0.0000735228,0.0004657157,0.0001822976,0.002689619],"genre_scores_gemma":[0.9818429,0.003744919,0.009756098,0.0001326705,0.00002666965,0.0001180936,0.001016668,0.00005895089,0.003302886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335527,"threshold_uncertainty_score":0.004467785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02294972621914932,"score_gpt":0.2933851972669671,"score_spread":0.2704354710478178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}