{"id":"W2804900747","doi":"10.1016/j.bbagen.2018.05.016","title":"Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation","year":2018,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"David F. Rankin College of Business, Southern Arkansas University; Department of Biotechnology, Government of West Bengal; Austrian Centre of Industrial Biotechnology; University of Tokyo; Advanced Foods and Materials Canada; Harvard Medical School","keywords":"Ubiquitin; Carcinogenesis; Biology; Deubiquitinating enzyme; Germline mutation; Somatic cell; Mutation; Point mutation; DNA damage; Germline; Cell biology; Cancer research; Cell growth; Suppressor; Mdm2; Cancer; Genetics; Apoptosis; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001212504,0.000437081,0.0002577954,0.0002454921,0.0002250534,0.0002458751,0.0003434643,0.0003941525,0.003961915],"category_scores_gemma":[0.0001932965,0.0001466746,0.0003884938,0.0002566272,0.0006064169,0.0001867377,0.0002243468,0.0006198605,0.0009654693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386167,"about_ca_system_score_gemma":0.0002628609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006623564,"about_ca_topic_score_gemma":0.0005440605,"domain_scores_codex":[0.9998767,0.00002573384,0.00002426703,0.00002212868,0.00002468722,0.00002634074],"domain_scores_gemma":[0.9998416,0.00002666105,0.00005303397,0.00002859413,0.000008630155,0.00004155029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006154127,0.0001197633,0.0004553802,0.00006340379,0.00003360869,0.0004867222,0.00001883853,0.0002896304,0.9949889,0.0008797709,0.0002050554,0.001843622],"study_design_scores_gemma":[0.0001289776,0.0002579363,0.001876138,0.000009661544,0.00003688942,0.001243729,0.00003102258,0.00130447,0.9905186,0.000145202,0.004437585,0.000009837436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947652,0.0006031659,0.00228179,0.0001784239,0.0001273451,0.00003341343,0.0005767936,0.0001108433,0.001323063],"genre_scores_gemma":[0.9977205,0.0002014275,0.0006599332,0.0000357822,0.00001106377,0.00001811174,0.0003200628,0.00002095592,0.001012066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003961915,"threshold_uncertainty_score":0.01325393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007417599122346553,"score_gpt":0.2236302265529881,"score_spread":0.2162126274306415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}