{"id":"W2804936366","doi":"10.1007/s00204-018-2222-z","title":"Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicity","year":2018,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"MedGenesis Therapeutix (Canada)","funders":"Pfizer; University of California, Davis; University of Bristol; Michael J. Fox Foundation for Parkinson's Research","keywords":"Glial cell line-derived neurotrophic factor; Neurotrophic factors; Medicine; Anesthesia; Putamen; Spinal cord; Endocrinology; Internal medicine; Pharmacology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163775,0.0002783638,0.0003843273,0.0001451622,0.0001450555,0.000229501,0.0002582779,0.0002387938,0.0002941001],"category_scores_gemma":[0.0001120314,0.00009496532,0.0001804484,0.0001150171,0.0003498117,0.0002206764,0.0001711211,0.0003517792,0.00009894192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003231535,"about_ca_system_score_gemma":0.0002915504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002898192,"about_ca_topic_score_gemma":0.004781242,"domain_scores_codex":[0.9999119,0.000009893672,0.000005888746,0.00003182946,0.00001782716,0.00002261602],"domain_scores_gemma":[0.9999309,0.000008101867,0.00002643081,0.00001396314,0.000008247115,0.00001242588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188326,0.0000440655,0.0001927672,0.00003595174,0.000006970366,0.00006224743,0.000046434,0.00007058321,0.9970552,0.00003138121,0.000019385,0.002216167],"study_design_scores_gemma":[0.00005558013,0.002556888,0.004342662,0.000008172996,0.00005560171,0.0003696418,0.00004072014,0.0009584656,0.9897645,0.00003260091,0.001808171,0.000007036195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977441,0.0007755464,0.001087161,0.0000295828,0.000009435891,0.00002483372,0.00005757238,0.00002094942,0.00025094],"genre_scores_gemma":[0.9961432,0.0007126768,0.002187964,0.0000180288,0.00001156114,0.00004589703,0.00009348548,0.00001273994,0.0007746277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002898192,"threshold_uncertainty_score":0.005762696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.023315063512891,"score_gpt":0.2834262286154777,"score_spread":0.2601111651025867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}