{"id":"W2805015289","doi":"10.1039/c8sc01790e","title":"Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue","year":2018,"lang":"en","type":"article","venue":"Chemical Science","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"H2020 European Research Council","keywords":"Native chemical ligation; Chemical synthesis; Amyloid (mycology); Chemistry; Chemical modification; β amyloid; Amyloid fibril; Biochemistry; Biophysics; Combinatorial chemistry; Amyloid β; In vitro; Biology; Medicine; Alzheimer's disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0001310986,0.0001191269,0.0002365737,0.00005701319,0.00009131119,0.00002543931,0.0001564612,0.0000518007,0.00005580472],"category_scores_gemma":[0.0004560423,0.00007951456,0.00005752396,0.0004318262,0.003442639,0.0001322947,0.0001681952,0.00008363582,0.00003744799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006472861,"about_ca_system_score_gemma":0.0002822396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003910944,"about_ca_topic_score_gemma":3.025561e-7,"domain_scores_codex":[0.9985241,0.00001199084,0.0001475843,0.0003775521,0.0005302376,0.0004085542],"domain_scores_gemma":[0.9990093,0.00005081229,0.00003290968,0.0002247298,0.0001765182,0.0005057029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002438626,0.0003172761,0.001113323,0.00003963687,0.0001237909,0.000009193097,0.00005920152,1.030484e-8,0.9969984,0.00004372933,0.00009130542,0.000960322],"study_design_scores_gemma":[0.0003887984,0.0001607913,0.001123677,0.00009615641,0.00009393029,0.00002962012,0.00003105551,0.0004021645,0.9975197,0.00006219809,0.000005856865,0.00008605829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998621,0.0003451239,0.000009336245,0.0002488217,0.00002254597,0.0001797531,0.000005021125,0.00002691086,0.0005415162],"genre_scores_gemma":[0.9991071,0.000009645343,0.0006984176,0.00003412096,0.00009614252,0.00002575281,0.000002034092,0.00000755057,0.00001920239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003351328,"threshold_uncertainty_score":0.9992694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0369999234576104,"score_gpt":0.2853316773171973,"score_spread":0.2483317538595869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}