{"id":"W2805086678","doi":"10.1016/j.eururo.2018.05.005","title":"Long-term Safety and Efficacy of Mirabegron and Solifenacin in Combination Compared with Monotherapy in Patients with Overactive Bladder: A Randomised, Multicentre Phase 3 Study (SYNERGY II)","year":2018,"lang":"en","type":"article","venue":"European Urology","topic":"Urinary Bladder and Prostate Research","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Health Sciences Centre","funders":"Astellas Pharma Europe; Astellas Pharma","keywords":"Mirabegron; Solifenacin; Medicine; Overactive bladder; Urology; Safety profile; Tolterodine; Combination therapy; Extended release; Internal medicine; Adverse effect; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000352894,0.0001628563,0.0004035784,0.0002295994,0.00005957514,0.000008094103,0.00005584025,0.00002911018,0.00003448686],"category_scores_gemma":[0.00004642182,0.00011814,0.00001262108,0.0001708708,0.0002672484,0.00008338624,0.00006115592,0.0002069664,0.000002148622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002728375,"about_ca_system_score_gemma":0.00003647587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006470348,"about_ca_topic_score_gemma":0.0001951408,"domain_scores_codex":[0.998258,0.0006857891,0.0002977371,0.0003380955,0.0001767788,0.0002436141],"domain_scores_gemma":[0.9992878,0.0002092722,0.0001109496,0.000185153,0.0001140773,0.00009277865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2685297,0.006268213,0.7090079,0.00002252729,0.0001463478,0.0001831015,0.008903326,0.0000101939,0.0001464292,0.000003279058,0.000005879294,0.006773123],"study_design_scores_gemma":[0.2640173,0.02136466,0.7139668,0.00003006704,0.00004223035,0.00001048549,0.0001514992,0.0002428053,0.00004802406,0.000001037729,0.00004250332,0.00008254092],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971382,0.0001024796,0.00003325875,0.000142756,0.00001415378,0.001834153,0.00000646475,0.0000115331,0.0007169792],"genre_scores_gemma":[0.9996685,0.00006680264,0.00003467959,0.0000849549,0.00001965225,0.000007566707,0.00003935397,0.00002913464,0.00004929612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01509645,"threshold_uncertainty_score":0.4817608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219313888682709,"score_gpt":0.2894866163821063,"score_spread":0.2772934774952792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}