{"id":"W2805205511","doi":"10.1016/j.mrgentox.2018.05.020","title":"Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488","year":2018,"lang":"en","type":"article","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Health and Environmental Sciences Institute","keywords":"Spermatogenesis; Germ cell; Andrology; Somatic cell; Sperm; Seminiferous tubule; Biology; Epididymis; Population; Genotoxicity; Sertoli cell; Genetics; Internal medicine; Toxicity; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006476016,0.0005041048,0.0003611045,0.0005944284,0.0001592971,0.0004790986,0.0007297512,0.0005367394,0.005741342],"category_scores_gemma":[0.0006994725,0.0002645406,0.001132529,0.0006053512,0.0001511901,0.0002570866,0.0003441436,0.0005409943,0.00106348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005873073,"about_ca_system_score_gemma":0.0008091689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0119918,"about_ca_topic_score_gemma":0.01561674,"domain_scores_codex":[0.9997684,0.00006784449,0.00001529873,0.00004210624,0.000077167,0.00002930298],"domain_scores_gemma":[0.9996314,0.0001503555,0.00004811474,0.00003671649,0.0001131062,0.00002022478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003144584,0.0001248188,0.009755014,0.0006622947,0.0001061815,0.0002015042,0.00008114607,0.9192356,0.04362658,0.004526202,0.003067568,0.01829865],"study_design_scores_gemma":[0.00008943377,0.0009006609,0.009925594,0.0001073308,0.000173044,0.0001801636,0.00009349137,0.9213802,0.03215734,0.003976681,0.03095135,0.00006463876],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5908979,0.002768737,0.3150038,0.0004948286,0.0002249917,0.0008229957,0.03241297,0.002557959,0.05481581],"genre_scores_gemma":[0.8727862,0.001802424,0.09564362,0.0001896153,0.00001349414,0.000974411,0.0128431,0.0002423664,0.01550475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0119918,"threshold_uncertainty_score":0.023844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04950297907320196,"score_gpt":0.3484969216576423,"score_spread":0.2989939425844404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}