{"id":"W2805205511","doi":"10.1016/j.mrgentox.2018.05.020","title":"Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488","year":2018,"lang":"en","type":"article","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Health and Environmental Sciences Institute","keywords":"Spermatogenesis; Germ cell; Andrology; Somatic cell; Sperm; Seminiferous tubule; Biology; Epididymis; Population; Genotoxicity; Sertoli cell; Genetics; Internal medicine; Toxicity; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005317075,0.0002069574,0.0002202002,0.0002057463,0.0004470352,0.00003200462,0.0001310012,0.000206121,0.000126888],"category_scores_gemma":[0.0002811741,0.0002178181,0.00004229882,0.0001876323,0.0005713069,0.00001266233,0.0003866985,0.00008356936,0.00001515987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007059174,"about_ca_system_score_gemma":0.00006532023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006866639,"about_ca_topic_score_gemma":0.00008005284,"domain_scores_codex":[0.9981657,0.00015477,0.0004719213,0.000499047,0.0003108082,0.000397723],"domain_scores_gemma":[0.9991043,0.0001745458,0.0001157716,0.0002894131,0.00009962133,0.0002163268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009205498,0.0001093356,0.03183628,0.0000251541,0.00003287733,0.00000628351,0.0001635075,0.01864303,0.936627,0.000002119447,0.00003923503,0.01242315],"study_design_scores_gemma":[0.0005739124,0.001501096,0.08904794,0.000008105247,0.00003668841,0.00005145996,0.0005121601,0.03526837,0.8715764,0.00002241128,0.001145502,0.0002559281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935669,0.0002827655,0.005262092,0.00008780578,0.00004650126,0.0005829944,0.0001060638,0.000008907412,0.00005597404],"genre_scores_gemma":[0.9886111,0.00007418654,0.01061405,0.0002709443,0.000137492,0.00003174011,0.00006594432,0.00003056088,0.0001639648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06505054,"threshold_uncertainty_score":0.8882364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04950297907320196,"score_gpt":0.3484969216576423,"score_spread":0.2989939425844404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}