{"id":"W2805277822","doi":"10.1007/s10637-018-0618-5","title":"Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells","year":2018,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Centre for Drug Research and Development","funders":"","keywords":"S1PR1; Carboplatin; Sphingosine; Antibody; Sphingosine-1-phosphate; Cancer research; Sphingosine-1-phosphate receptor; Cytotoxicity; Pharmacology; Monoclonal antibody; Sphingolipid; Cancer cell; Chemistry; Cell growth; Receptor; Cancer; Biology; Medicine; Immunology; Internal medicine; Biochemistry; In vitro; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005345872,0.0002265298,0.000347456,0.00004907134,0.0001665517,0.00002083063,0.0004575662,0.0001209701,0.00008399223],"category_scores_gemma":[0.0001450358,0.0001509987,0.0001632952,0.0002509441,0.0004721881,0.0000131607,0.0001960849,0.0001369564,0.000006787588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001003148,"about_ca_system_score_gemma":0.0002756095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005620015,"about_ca_topic_score_gemma":0.00003137116,"domain_scores_codex":[0.9981794,0.0002131004,0.0005707182,0.0004135958,0.0003978014,0.000225384],"domain_scores_gemma":[0.9986835,0.00006196608,0.0004190191,0.0004536818,0.0002449673,0.0001369193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001134138,0.0001333649,0.09062224,0.00003644251,0.0001062122,2.954009e-7,0.000300921,0.0001331446,0.9069542,0.00006394884,0.001200081,0.0003357344],"study_design_scores_gemma":[0.001644593,0.0003576706,0.0798035,0.000107792,0.00006928747,0.000002075822,0.00004801874,0.00004841241,0.9161115,0.00004348073,0.00158867,0.000175026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998051,0.000196275,0.00002667621,0.0002180783,0.0007749437,0.0004628399,0.00009062816,0.00001153917,0.0001680355],"genre_scores_gemma":[0.9976602,0.0000515095,0.00018591,0.0002915753,0.001410782,0.00001148129,0.00009884252,0.0000300556,0.0002596323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01081873,"threshold_uncertainty_score":0.615755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269533112936384,"score_gpt":0.3209698053832642,"score_spread":0.3082744742539004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}