{"id":"W2805277822","doi":"10.1007/s10637-018-0618-5","title":"Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells","year":2018,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Centre for Drug Research and Development","funders":"","keywords":"S1PR1; Carboplatin; Sphingosine; Antibody; Sphingosine-1-phosphate; Cancer research; Sphingosine-1-phosphate receptor; Cytotoxicity; Pharmacology; Monoclonal antibody; Sphingolipid; Cancer cell; Chemistry; Cell growth; Receptor; Cancer; Biology; Medicine; Immunology; Internal medicine; Biochemistry; In vitro; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004841833,0.0005782543,0.0005672197,0.0004786017,0.0002851072,0.000214342,0.0004988199,0.0004277731,0.002634642],"category_scores_gemma":[0.0002209168,0.0002331478,0.0003948659,0.0002718947,0.0002900547,0.0003659813,0.0001252545,0.001246852,0.0003894295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003585186,"about_ca_system_score_gemma":0.0005602046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001395238,"about_ca_topic_score_gemma":0.001666784,"domain_scores_codex":[0.9998513,0.00003731492,0.000007267487,0.00002085384,0.00002337175,0.00005981794],"domain_scores_gemma":[0.9998288,0.00004983366,0.0000247894,0.00002012938,0.0000229557,0.00005344709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01152587,0.01995133,0.0008130421,0.0003447946,0.000126816,0.0002447825,0.0001521435,0.002217885,0.9401752,0.001023016,0.001328693,0.02209639],"study_design_scores_gemma":[0.003228921,0.1135468,0.004322832,0.00001919039,0.0002989233,0.000426381,0.00006098706,0.003541955,0.8688834,0.0001909139,0.005466454,0.00001318207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918847,0.002694593,0.001252696,0.0003064934,0.0001442621,0.0002130565,0.0003944204,0.000102203,0.003007547],"genre_scores_gemma":[0.9936428,0.002107614,0.0006508006,0.00008347169,0.00005339534,0.0001203315,0.0005087081,0.00001275811,0.002820124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002634642,"threshold_uncertainty_score":0.008813739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269533112936384,"score_gpt":0.3209698053832642,"score_spread":0.3082744742539004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}