{"id":"W2805347888","doi":"10.1080/02648725.2018.1471567","title":"Viruses, IRESs, and a universal translation initiation mechanism","year":2018,"lang":"en","type":"review","venue":"Biotechnology and Genetic Engineering Reviews","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Technology Futures","keywords":"Internal ribosome entry site; Eukaryotic translation; Eukaryotic initiation factor; Translation (biology); Biology; Initiation factor; EIF4E; Computational biology; Eukaryotic translation initiation factor 4 gamma; Ribosome; Genetics; RNA; Cell biology; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000180797,0.0002624803,0.0009769708,0.0004077989,0.0000864199,0.0000125585,0.00006787234,0.0009283245,0.0000209536],"category_scores_gemma":[0.00009673236,0.0002103058,0.0001153013,0.0002978523,0.0001478081,0.00003302088,0.00005694076,0.0005111399,0.00003935778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003527023,"about_ca_system_score_gemma":0.00005087098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005350786,"about_ca_topic_score_gemma":0.000002145389,"domain_scores_codex":[0.9989827,0.00005717314,0.0003766173,0.000332936,0.00004945086,0.0002010822],"domain_scores_gemma":[0.9995054,0.00003800713,0.0001013772,0.0002807818,0.00002198074,0.00005245102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002958121,0.00001312375,0.000002510969,0.006588228,0.0000882829,0.00001080961,0.000009628185,5.111218e-8,0.0001458774,0.0005639443,0.0000537674,0.9925208],"study_design_scores_gemma":[0.0001979805,0.0003006698,0.00001891848,0.004998035,0.0005430047,0.0005066067,0.000001657555,0.00008587622,0.00005724844,0.00003213019,0.9930867,0.0001711721],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001575949,0.9957526,0.002825965,0.00009017028,0.00011192,0.0009257963,0.000006636934,0.0001033101,0.0000259948],"genre_scores_gemma":[0.00003219577,0.9963957,0.003310065,0.00002087595,0.00007395277,0.00007715088,0.00001805352,0.00002866135,0.00004334652],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9930329,"threshold_uncertainty_score":0.8576021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0742972725499003,"score_gpt":0.3385265716737842,"score_spread":0.2642292991238839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}