{"id":"W2805347888","doi":"10.1080/02648725.2018.1471567","title":"Viruses, IRESs, and a universal translation initiation mechanism","year":2018,"lang":"en","type":"review","venue":"Biotechnology and Genetic Engineering Reviews","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Technology Futures","keywords":"Internal ribosome entry site; Eukaryotic translation; Eukaryotic initiation factor; Translation (biology); Biology; Initiation factor; EIF4E; Computational biology; Eukaryotic translation initiation factor 4 gamma; Ribosome; Genetics; RNA; Cell biology; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000473654,0.0008186615,0.0009927687,0.001495811,0.0003744385,0.001312987,0.0007743204,0.001530437,0.002215378],"category_scores_gemma":[0.0004301036,0.0003003327,0.0003639681,0.001349628,0.001004762,0.002198555,0.0006879524,0.002248364,0.001680783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008507716,"about_ca_system_score_gemma":0.001219804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006500887,"about_ca_topic_score_gemma":0.0006155924,"domain_scores_codex":[0.9997935,0.00003241656,0.00002730471,0.00005086973,0.00006831262,0.00002768716],"domain_scores_gemma":[0.9997934,0.00008922739,0.00003717937,0.00000817929,0.00004713523,0.00002494642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008681083,0.00007638675,0.0002794522,0.01706612,0.00005852956,0.0004600911,0.000193417,0.0006610795,0.008379809,0.06051106,0.0309945,0.8812327],"study_design_scores_gemma":[0.00000420156,0.00004845419,0.0002042275,0.001079079,0.00001849826,0.0008510936,0.00003913849,0.00006485958,0.0007777103,0.004907246,0.9919946,0.00001083571],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001359851,0.9971653,0.0003032796,0.0002941362,0.0002837082,0.000003990821,0.0000093256,0.000009872611,0.00179439],"genre_scores_gemma":[0.001678726,0.9961005,0.0003701463,0.00026095,0.000309096,0.000009470233,0.00002572051,0.000002186681,0.001243158],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002215378,"threshold_uncertainty_score":0.007411182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0742972725499003,"score_gpt":0.3385265716737842,"score_spread":0.2642292991238839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}