{"id":"W2805363895","doi":"10.1186/s12883-018-1086-4","title":"Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy","year":2018,"lang":"en","type":"article","venue":"BMC Neurology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Alberta","funders":"","keywords":"Dapagliflozin; Pentylenetetrazol; Epilepsy; Medicine; Placebo; Anesthesia; Pharmacology; Diabetes mellitus; Internal medicine; Endocrinology; Anticonvulsant; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002231032,0.0006928385,0.000780886,0.0005389064,0.0001436582,0.0002268923,0.0003486714,0.0003475205,0.001233107],"category_scores_gemma":[0.0001391582,0.0001805201,0.0003128099,0.0002844594,0.0003027568,0.0002970669,0.0001455849,0.001050337,0.000241482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004371358,"about_ca_system_score_gemma":0.0003712385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001050611,"about_ca_topic_score_gemma":0.002304791,"domain_scores_codex":[0.9998046,0.00002928018,0.00002524827,0.00003473091,0.00004102195,0.00006518856],"domain_scores_gemma":[0.999803,0.00001504446,0.00007677863,0.00001771953,0.00001410103,0.00007345752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006753213,0.00193732,0.0009027856,0.000112473,0.00004204784,0.00009815372,0.00002741815,0.0002825381,0.9831769,0.00006452284,0.000381918,0.006220785],"study_design_scores_gemma":[0.001483149,0.04312066,0.01878138,0.00003196554,0.000165477,0.0003682805,0.00008657373,0.003807637,0.9296905,0.00009619492,0.00234061,0.00002763371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963204,0.0007913102,0.001175851,0.0002109465,0.00006753524,0.00008386481,0.0005763686,0.0001629786,0.0006107772],"genre_scores_gemma":[0.9936027,0.00117791,0.001824492,0.0001374854,0.00003246002,0.000242495,0.0009711557,0.00002299274,0.001988289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001233107,"threshold_uncertainty_score":0.004125118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03075123895960597,"score_gpt":0.2743721078870152,"score_spread":0.2436208689274092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}