{"id":"W2805408455","doi":"10.3389/fendo.2018.00318","title":"Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions","year":2018,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Temozolomide; Pituitary tumors; Medicine; Oncology; Pituitary adenoma; Cancer research; Glioblastoma; Pituitary neoplasm; Internal medicine; Pituitary gland; Bioinformatics; Biology; Adenoma; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000640392,0.0005508581,0.0008375524,0.001425582,0.0002747131,0.0009877378,0.0006026818,0.001017622,0.002877341],"category_scores_gemma":[0.0008124634,0.0001898155,0.0003497339,0.001619681,0.000536929,0.001679496,0.0005766411,0.001612127,0.0007915515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006246304,"about_ca_system_score_gemma":0.001612695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140703,"about_ca_topic_score_gemma":0.002552613,"domain_scores_codex":[0.9998641,0.00002694102,0.00002340225,0.00002551507,0.00004236137,0.00001777977],"domain_scores_gemma":[0.9995847,0.0002077801,0.00005546372,0.000009446991,0.0001018834,0.00004073694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001082599,0.00007619293,0.0003966078,0.01569807,0.00006659465,0.0004250797,0.0001354471,0.0004198608,0.00172147,0.00667426,0.02898601,0.9452922],"study_design_scores_gemma":[0.00001320701,0.0001073621,0.001215707,0.003994883,0.0001235325,0.001953594,0.0001983734,0.00015467,0.0004111092,0.004679097,0.9871258,0.0000225652],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001280294,0.9984042,0.00008160705,0.0007322174,0.000145636,0.000001539572,0.00001042805,0.000004696304,0.0004915386],"genre_scores_gemma":[0.0006989497,0.9985433,0.0001111535,0.0002177311,0.0002090356,0.000002097915,0.00001457486,6.971998e-7,0.0002025036],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002877341,"threshold_uncertainty_score":0.009625733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05214073578697633,"score_gpt":0.3380654318103982,"score_spread":0.2859246960234219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}