{"id":"W2805408455","doi":"10.3389/fendo.2018.00318","title":"Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions","year":2018,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"","keywords":"Temozolomide; Pituitary tumors; Medicine; Oncology; Pituitary adenoma; Cancer research; Glioblastoma; Pituitary neoplasm; Internal medicine; Pituitary gland; Bioinformatics; Biology; Adenoma; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007903335,0.0005016407,0.002000111,0.0007846056,0.0001211712,0.00002311748,0.00009967062,0.000268652,0.00003215332],"category_scores_gemma":[0.00004000845,0.0003930468,0.0001869597,0.000284213,0.0004075188,0.00004937965,0.0001354457,0.0005466667,0.00001083928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005189046,"about_ca_system_score_gemma":0.0001243986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007648849,"about_ca_topic_score_gemma":0.0000626831,"domain_scores_codex":[0.9978926,0.0001622735,0.0005161136,0.0007349756,0.0001267228,0.0005673601],"domain_scores_gemma":[0.999142,0.00007946838,0.0001797262,0.000388919,0.00002610613,0.0001838007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003022977,0.0002639751,0.009210256,0.004037268,0.0005362931,0.0006459616,0.0001225762,1.03159e-8,4.659474e-8,0.001068322,0.06012989,0.9239551],"study_design_scores_gemma":[0.001176647,0.0002879537,0.0007309778,0.003864131,0.001130209,0.001163041,0.0002685313,0.000002927029,6.955977e-7,0.0006387166,0.9904536,0.0002825801],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008753478,0.9949709,0.00003560182,0.0006518508,0.00266465,0.001025372,0.00005311241,0.00007078505,0.0004401839],"genre_scores_gemma":[0.00003780596,0.9971293,0.00137016,0.00003821128,0.0008827932,0.0002417989,0.0001439054,0.00005438888,0.0001016559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9303237,"threshold_uncertainty_score":0.9998521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05214073578697633,"score_gpt":0.3380654318103982,"score_spread":0.2859246960234219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}