{"id":"W2805419235","doi":"10.1038/s41598-018-21134-1","title":"Generation of a Dual-Target, Safe, Inexpensive Microbicide that Protects Against HIV-1 and HSV-2 Disease","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Caulobacter crescentus; Microbicide; Virology; Microbicides for sexually transmitted diseases; Recombinant DNA; Biology; Microbiology; Immunology; Medicine; Human immunodeficiency virus (HIV); Gene; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002140675,0.0003262802,0.0001826416,0.0002744853,0.0001256597,0.0002756465,0.0002683928,0.0004536665,0.0007018091],"category_scores_gemma":[0.0001024591,0.00009862061,0.0002545099,0.0001157755,0.0001817263,0.0001709652,0.0002123273,0.0004508671,0.0001421947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002343592,"about_ca_system_score_gemma":0.0002803617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005752394,"about_ca_topic_score_gemma":0.001183014,"domain_scores_codex":[0.9998977,0.00001430546,0.000004303925,0.00001603795,0.00004427203,0.00002340224],"domain_scores_gemma":[0.9999495,0.00000465582,0.0000140942,0.00000517708,0.000008705835,0.00001793174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004498728,0.00005581744,0.0001213831,0.00006391633,0.000006080352,0.00005137517,0.000006223131,0.0001293041,0.9950652,0.0001420708,0.00006585218,0.004247868],"study_design_scores_gemma":[0.00007859905,0.001927095,0.002980197,0.00003131688,0.00003343682,0.0006406606,0.00002648056,0.001459953,0.983301,0.000102786,0.009406918,0.00001152189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959694,0.01343849,0.02204591,0.0005203628,0.0001253748,0.0002579762,0.0004335039,0.0001270766,0.003357181],"genre_scores_gemma":[0.9669281,0.004367657,0.02471598,0.0001750907,0.00002741301,0.00008111262,0.0004295685,0.00001389623,0.003261134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007018091,"threshold_uncertainty_score":0.002347827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04341225185904579,"score_gpt":0.2890089442954994,"score_spread":0.2455966924364536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}