{"id":"W2805469564","doi":"10.2967/jnumed.118.209130","title":"Impact of Reference and Target Region Selection on Amyloid PET SUV Ratios in the Phase 1b PRIME Study of Aducanumab","year":2018,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"White matter; Nuclear medicine; Pons; Pittsburgh compound B; Standardized uptake value; Cerebellar cortex; Medicine; Grey matter; Cerebellum; Alzheimer's disease; Psychology; Pathology; Internal medicine; Positron emission tomography; Magnetic resonance imaging; Radiology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008399745,0.0007536454,0.001620475,0.000214315,0.000145397,0.0007541652,0.0004052698,0.0005952056,0.001397196],"category_scores_gemma":[0.006614121,0.0003742171,0.001114624,0.0002387098,0.0004167187,0.0004291663,0.0002338661,0.00100532,0.0002535399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445728,"about_ca_system_score_gemma":0.0004068784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003408304,"about_ca_topic_score_gemma":0.000742997,"domain_scores_codex":[0.9960486,0.00303301,0.000162479,0.000334379,0.0003294886,0.00009209588],"domain_scores_gemma":[0.9973369,0.001802876,0.0004522165,0.0001934653,0.0001395967,0.0000748249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5722113,0.003439771,0.02529517,0.001668991,0.007790017,0.0002692326,0.000477864,0.00872409,0.1186757,0.001131958,0.003487101,0.2568287],"study_design_scores_gemma":[0.126043,0.3928031,0.2823268,0.0004039004,0.02198975,0.001714673,0.0003140517,0.02970341,0.1117456,0.003412694,0.02927884,0.0002643047],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783739,0.008605321,0.007745695,0.0003244896,0.0001406961,0.0006232557,0.0004852406,0.0002798999,0.003421652],"genre_scores_gemma":[0.9925229,0.000506519,0.005205762,0.0002086442,0.00004650467,0.0005860105,0.0002189509,0.00008621542,0.0006183899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008399745,"threshold_uncertainty_score":0.04442263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05801190120357905,"score_gpt":0.402544320622462,"score_spread":0.344532419418883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}