{"id":"W2805560189","doi":"10.1016/j.ejmech.2018.06.007","title":"Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Meropenem; Antimicrobial; Carbapenem; Microbiology; Chemistry; Enterobacteriaceae; Antibiotics; Imipenem; Beta-Lactamase Inhibitors; Escherichia coli; Antibiotic resistance; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219207,0.0003985663,0.0008301495,0.0003271068,0.0001654413,0.000260178,0.0002635389,0.0002883576,0.001409278],"category_scores_gemma":[0.0004042997,0.0002468887,0.0004977721,0.0003024095,0.0002237082,0.0003433494,0.0002238701,0.0004018676,0.0001431232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009750096,"about_ca_system_score_gemma":0.0002396195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002653532,"about_ca_topic_score_gemma":0.0008187992,"domain_scores_codex":[0.9997457,0.00008455037,0.0000239063,0.00004250227,0.00005835747,0.00004487966],"domain_scores_gemma":[0.9998129,0.00006786951,0.00003445731,0.00001605167,0.00003130923,0.00003741939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005192396,0.001058513,0.0008392759,0.0003778882,0.0001170473,0.0001622935,0.00007761852,0.0007300631,0.9764519,0.00007388654,0.0001428388,0.01477622],"study_design_scores_gemma":[0.0005066423,0.03608494,0.01204322,0.00003946993,0.000443049,0.0004680352,0.0001598979,0.001598708,0.9446447,0.00006124011,0.00391097,0.000039088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958047,0.002882161,0.0002241067,0.0000581092,0.00005835649,0.00003178063,0.0001401353,0.00001369253,0.000786932],"genre_scores_gemma":[0.9961796,0.001943958,0.0009954135,0.00002773092,0.00003574022,0.00002225865,0.0001244754,0.000005520374,0.0006653744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409278,"threshold_uncertainty_score":0.004714549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007735915261119644,"score_gpt":0.208310550743658,"score_spread":0.2005746354825383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}