{"id":"W2805560189","doi":"10.1016/j.ejmech.2018.06.007","title":"Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1","year":2018,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Meropenem; Antimicrobial; Carbapenem; Microbiology; Chemistry; Enterobacteriaceae; Antibiotics; Imipenem; Beta-Lactamase Inhibitors; Escherichia coli; Antibiotic resistance; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006283341,0.0001629322,0.0003325634,0.00003695262,0.00005915422,0.000008935524,0.000354972,0.00004125499,0.000008477708],"category_scores_gemma":[0.00076103,0.000121145,0.00008626012,0.0001105637,0.0008376634,0.000009820481,0.0001186904,0.0001486471,2.759924e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001706617,"about_ca_system_score_gemma":0.0001137021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004162027,"about_ca_topic_score_gemma":0.000001698601,"domain_scores_codex":[0.9984301,0.0002799979,0.0006828586,0.0001982445,0.0002754754,0.0001333569],"domain_scores_gemma":[0.9979227,0.00006770493,0.001184028,0.0003269766,0.0004219675,0.00007657717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003483641,0.00009495471,0.005682268,0.0006251103,0.0001154326,0.000005096951,0.0004011286,0.000002789547,0.9922918,0.00001226692,0.0002923322,0.0001284219],"study_design_scores_gemma":[0.001136699,0.0004963722,0.1269007,0.00176821,0.00009277016,0.00002110265,0.0001064784,0.00000136743,0.8693236,0.00001071782,0.00005810699,0.00008390742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987127,0.0002879489,0.0001489855,0.000161612,0.0001965506,0.0001129262,0.0000112685,0.000001925517,0.0003661075],"genre_scores_gemma":[0.9990347,0.0001167047,0.0004190352,0.00004354413,0.0002754213,2.960533e-7,0.00000829869,0.00002305486,0.00007893491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1229682,"threshold_uncertainty_score":0.494015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007735915261119644,"score_gpt":0.208310550743658,"score_spread":0.2005746354825383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}