{"id":"W2805583469","doi":"10.1111/hae.13489","title":"Past, present and future of haemophilia gene therapy: From vectors and transgenes to known and unknown outcomes","year":2018,"lang":"en","type":"review","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Hemophilia Society","funders":"","keywords":"Haemophilia; Medicine; Clinical trial; Genetic enhancement; Haemophilia A; Pace; Vector (molecular biology); Intensive care medicine; Bioinformatics; Gene; Genetics; Biology; Pediatrics; Pathology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001543003,0.0005574187,0.001036808,0.001838159,0.0003420569,0.001901343,0.0007114313,0.001328637,0.002172152],"category_scores_gemma":[0.002039544,0.0002381747,0.0004799641,0.001803899,0.001669709,0.003599002,0.0007132826,0.002753738,0.0009321398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008802971,"about_ca_system_score_gemma":0.001659253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008416345,"about_ca_topic_score_gemma":0.0009867304,"domain_scores_codex":[0.9994965,0.0001351889,0.00007867598,0.00006897158,0.0001897688,0.00003091043],"domain_scores_gemma":[0.9988542,0.0007606755,0.0001030643,0.0000450053,0.000185914,0.00005115844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009374844,0.0000716764,0.0002477421,0.02295115,0.0000815865,0.0002386246,0.000327652,0.0004198306,0.002028353,0.03393399,0.03935343,0.9002522],"study_design_scores_gemma":[0.00001142875,0.00007164157,0.0004037711,0.005984168,0.00006944659,0.0009397337,0.0001377388,0.00006806181,0.0003702017,0.009800089,0.9821263,0.00001744109],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007442449,0.997933,0.0001297774,0.0009519623,0.0002260477,0.000001986387,0.00000750874,0.000004210387,0.0006709885],"genre_scores_gemma":[0.0006981878,0.9981622,0.0001599987,0.0004543751,0.0002311204,0.000003686564,0.000009000093,0.000001733195,0.0002797394],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002172152,"threshold_uncertainty_score":0.008160233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07062798449537222,"score_gpt":0.3621399495781776,"score_spread":0.2915119650828054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}