{"id":"W2805583469","doi":"10.1111/hae.13489","title":"Past, present and future of haemophilia gene therapy: From vectors and transgenes to known and unknown outcomes","year":2018,"lang":"en","type":"review","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Hemophilia Society","funders":"","keywords":"Haemophilia; Medicine; Clinical trial; Genetic enhancement; Haemophilia A; Pace; Vector (molecular biology); Intensive care medicine; Bioinformatics; Gene; Genetics; Biology; Pediatrics; Pathology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003201565,0.000929545,0.003275308,0.0004889914,0.000163231,0.00006280949,0.0002427861,0.0006727656,0.0001712721],"category_scores_gemma":[0.00002552811,0.0005834491,0.0004132869,0.0004212639,0.0005405633,0.00008274496,0.0002311198,0.0004328158,0.00002595682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006508989,"about_ca_system_score_gemma":0.0002265358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001267437,"about_ca_topic_score_gemma":0.00001897093,"domain_scores_codex":[0.9965414,0.0002236887,0.0008436696,0.001172204,0.0006175879,0.0006014471],"domain_scores_gemma":[0.9976723,0.0003356263,0.0002047587,0.0008703298,0.0001739219,0.0007430172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001698868,0.0002184588,0.002585506,0.005991192,0.00133705,0.0001261792,0.0007048267,2.119467e-8,0.00005627762,0.00002816119,0.002561524,0.9862209],"study_design_scores_gemma":[0.001669854,0.0008744178,0.006464846,0.003243191,0.001210674,0.0001256158,0.00003772969,0.000002711976,0.0001993677,0.0001247536,0.9855322,0.0005146218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05821221,0.9347362,0.000001830038,0.003368016,0.0003690384,0.002681008,0.0003740643,0.00005632055,0.0002013131],"genre_scores_gemma":[0.0007476973,0.9927764,0.0005721299,0.00009207786,0.003550338,0.000144314,0.0002346034,0.0001349961,0.00174746],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9857063,"threshold_uncertainty_score":0.9996617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07062798449537222,"score_gpt":0.3621399495781776,"score_spread":0.2915119650828054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}