{"id":"W2805605515","doi":"10.1038/s41598-018-24220-6","title":"Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Diabetic nephropathy; Glomerulosclerosis; NOX4; Fibrosis; Cancer research; Internal medicine; Endocrinology; Kidney; Diabetes mellitus; Chemistry; Medicine; NADPH oxidase; Proteinuria; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090839,0.0001740384,0.0002079919,0.000177449,0.0001381996,0.0001168369,0.0001024417,0.00008970939,0.00001308561],"category_scores_gemma":[0.0005120606,0.0001640494,0.00004795628,0.0003033936,0.0003566893,0.00001254032,0.0002417986,0.00009405922,0.00000652033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002300996,"about_ca_system_score_gemma":0.00006058045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000433808,"about_ca_topic_score_gemma":0.000139015,"domain_scores_codex":[0.9981264,0.00007308298,0.0004046737,0.0008236584,0.0001795737,0.0003925714],"domain_scores_gemma":[0.9992034,0.00001738276,0.0001686698,0.0004423171,0.0001016748,0.00006651135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001158167,0.00005551851,0.03003635,0.00004991239,0.00001140481,0.00001847576,0.000379601,0.000003805001,0.9681185,7.727308e-7,0.0002898713,0.001024198],"study_design_scores_gemma":[0.0001774357,0.0001233475,0.001115125,0.0001681027,0.000004423559,0.000007560331,0.0001163815,0.00006603137,0.9902381,0.000129161,0.007671988,0.00018237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978538,0.0002605248,0.0000156708,0.00007354215,0.001122167,0.0004214134,0.000006061367,0.00001458529,0.0002322396],"genre_scores_gemma":[0.9978819,0.000004944186,0.001052867,0.00001575337,0.0001619972,0.0000655456,0.00002127728,0.00001943774,0.0007762568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02892122,"threshold_uncertainty_score":0.6689742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009836781932287144,"score_gpt":0.2385077554208331,"score_spread":0.228670973488546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}