{"id":"W2805642491","doi":"10.1002/jcph.1133","title":"Development of a Physiologically Based Pharmacokinetic Model of Ethionamide in the Pediatric Population by Integrating Flavin‐Containing Monooxygenase 3 Maturational Changes Over Time","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Korea Health Industry Development Institute","keywords":"Ethionamide; Physiologically based pharmacokinetic modelling; Flavin-containing monooxygenase; Pharmacology; Pharmacokinetics; Population; Drug metabolism; Chemistry; Drug; Medicine; Monooxygenase; Metabolism; Biochemistry; Cytochrome P450; Antibiotics; Rifampicin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003508984,0.0001236269,0.0005163415,0.0001025349,0.00005719961,0.000002287314,0.000249257,0.0001149931,0.0001962457],"category_scores_gemma":[0.0001593601,0.00006159394,0.0001332531,0.0001798079,0.0001383786,0.00004348184,0.00001954878,0.0005633064,0.00000187894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002605509,"about_ca_system_score_gemma":0.000271065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003460003,"about_ca_topic_score_gemma":0.000008260457,"domain_scores_codex":[0.9975663,0.0004179857,0.001373748,0.0001060195,0.0003738209,0.0001620887],"domain_scores_gemma":[0.9976358,0.0009178895,0.001024998,0.00008334572,0.0002748088,0.00006308805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008328804,0.0008665305,0.004131849,0.0001020106,0.0001494125,0.00001186062,0.001496357,0.002033689,0.9782082,0.00004643605,0.001474296,0.003150571],"study_design_scores_gemma":[0.02407323,0.005873397,0.4370372,0.0005136863,0.002554765,0.00006128966,0.0008899467,0.425213,0.1009173,0.001712141,0.0006079637,0.0005460858],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948459,0.0001317549,0.002811741,0.001637772,0.0002561059,0.0002477064,0.000006820218,0.000004480793,0.00005771876],"genre_scores_gemma":[0.9910986,0.0001083408,0.00610415,0.00206752,0.0005686751,0.000004729119,0.00001172319,0.000009156063,0.00002704295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8772909,"threshold_uncertainty_score":0.2511728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06153868973222539,"score_gpt":0.4023979419875529,"score_spread":0.3408592522553275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}