{"id":"W2805728231","doi":"10.6000/1929-2279.2018.07.02.4","title":"Sildenafil Induces Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer HT-29 Cells","year":2018,"lang":"en","type":"article","venue":"Journal of cancer research updates","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Technology Planning Project of Guangdong Province; National Natural Science Foundation of China","keywords":"Sildenafil; cGMP-specific phosphodiesterase type 5; Apoptosis; Erectile dysfunction; Phosphodiesterase; Colorectal cancer; Cell cycle checkpoint; Cancer; Internal medicine; Chemistry; Cancer research; Medicine; Cell cycle; Endocrinology; Pharmacology; Biology; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007001804,0.0001861635,0.0003158769,0.0002613141,0.0002278951,0.000190166,0.0001233006,0.0001907195,0.00182065],"category_scores_gemma":[0.00008175965,0.00008617478,0.0002306034,0.0002538418,0.00007971565,0.00008377343,0.00008561525,0.0003727443,0.000414418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002637908,"about_ca_system_score_gemma":0.0002545422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004863829,"about_ca_topic_score_gemma":0.006511132,"domain_scores_codex":[0.9999028,0.00001301705,0.00001121562,0.0000173993,0.00002960248,0.00002594697],"domain_scores_gemma":[0.9999428,0.00001285868,0.000008809532,0.000007475134,0.00001408745,0.00001395165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000780186,0.0002761901,0.001579158,0.0001447792,0.00002542506,0.0004165306,0.00007754186,0.0001679927,0.9883012,0.0001724665,0.0006769391,0.007381541],"study_design_scores_gemma":[0.0002589512,0.003519671,0.07267365,0.00003187887,0.0001111497,0.001211306,0.0001573282,0.004720594,0.9016886,0.0001213256,0.01548636,0.00001914419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828074,0.009631632,0.001266157,0.0003251662,0.0001655549,0.00006370765,0.001196665,0.00008599013,0.004457713],"genre_scores_gemma":[0.9881562,0.004091516,0.001354027,0.0002012461,0.00003357891,0.00005054299,0.001751099,0.000007882253,0.004353899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004863829,"threshold_uncertainty_score":0.009671032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159033583566995,"score_gpt":0.3546657720791433,"score_spread":0.3330754362434734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}