{"id":"W2805734855","doi":"10.1056/nejmoa1804710","title":"Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2369,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Sunnybrook Hospital","funders":"National Cancer Institute; Canadian Cancer Society Research Institute; ECOG-ACRIN Cancer Research Group; Breast Cancer Research Foundation; Johns Hopkins University; American College of Radiology Imaging Network; Susan G. Komen for the Cure","keywords":"Adjuvant; Breast cancer; Adjuvant chemotherapy; Oncology; Medicine; Cancer; Chemotherapy; Gene expression; Gene; Cancer research; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002072281,0.0002236088,0.0006416059,0.0002337441,0.00009470189,0.0002610693,0.0002116429,0.0003435054,0.0007623051],"category_scores_gemma":[0.003077591,0.0001241096,0.0002751172,0.0003456115,0.0003515933,0.0002010845,0.000205869,0.0005965426,0.0001022376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002612366,"about_ca_system_score_gemma":0.0003538691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002065097,"about_ca_topic_score_gemma":0.000426929,"domain_scores_codex":[0.9991065,0.0006203394,0.00005175792,0.00007060388,0.0001066755,0.00004400684],"domain_scores_gemma":[0.997855,0.001353898,0.0004449138,0.0001060808,0.0000762288,0.0001638455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3168253,0.006121024,0.2615451,0.00110149,0.001096405,0.0002033055,0.0001471876,0.006971144,0.03033721,0.0005360782,0.001424007,0.3736918],"study_design_scores_gemma":[0.07769898,0.4170658,0.4503382,0.0003994634,0.002788525,0.001599314,0.0001104027,0.01210143,0.02615662,0.001764473,0.009901663,0.00007507672],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895146,0.008531518,0.0007388094,0.0002100267,0.00004503869,0.0001431815,0.00008444367,0.00001143444,0.0007209564],"genre_scores_gemma":[0.9975168,0.001250058,0.0007066689,0.0001259199,0.00003030407,0.00008591769,0.0001240447,0.000001769752,0.0001585524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072281,"threshold_uncertainty_score":0.01095939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030452404452895,"score_gpt":0.287832908951248,"score_spread":0.2775283849067191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}